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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Whey and soy protein supplements changes body composition in patients with Crohn's disease undergoing azathioprine and anti-TNF-alpha therapy

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Machado, Julia Figueiredo [1] ; Oya, Vanessa [1] ; Rodrigues Coy, Claudio Saddy [2] ; Morcillo, Andre Moreno [1] ; Severino, Silvana Dalge [1] ; Wu, Chao [3] ; Sgarbieri, Valdemiro Carlos [4] ; dos Santos Vilela, Maria Marluce [1]
Total Authors: 8
[1] Univ Campinas UNICAMP, Fac Med Sci, Dept Pediat, Ctr Invest Pediat, BR-13083970 Campinas, SP - Brazil
[2] Univ Estadual Campinas, Fac Med Sci, Coloproctol Unit, Gastroctr, Dept Surg, BR-13083878 Campinas, SP - Brazil
[3] Hilmar Cheese Co, Hilmar, CA - USA
[4] Univ Campinas UNICAMP, Food Engn Fac, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: NUTRICION HOSPITALARIA; v. 31, n. 4, p. 1603-1610, APR 2015.
Web of Science Citations: 4

Background: Crohn's disease (CD) is a chronic transmural inflammation of the gastrointestinal tract of unknown cause. Malnutrition associated with active CD has been reduced although obesity has increased. Dietary strategies such as those with high-protein have been proposed to reduce body fat. This study compares the effects of two supplements on the nutritional status of CD patients. Materials and Methods: 68 CD patients were randomized in two groups: whey protein group (WP) and soy protein group (SP). Using bioimpedance analysis, anthropometry and albumin and pre-albumin dosages the nutritional status was measured before starting the intervention and after 8 and 16 weeks. The disease activity was determined by Crohn's Disease Activity Index and serum C-reactive protein dosage and dietary intake by 24h dietary recalls. Results: Forty-one patients concluded the study and both supplements changed body composition similarly. Triceps skin fold thickness (p<0.001) and body fat percentage (p=0.001) decreased, whereas mid-arm muscle circumference (p=0.004), corrected arm muscle area (p=0.005) and body lean percentage (p=0.001) increased. Conclusions: For Crohn's disease patients undergoing anti TNF-alpha and azatioprine therapies, supplementation with whey and soy proteins changes body composition through reduction of body fat and thus contributes to control inflammation. (AU)

FAPESP's process: 11/04750-9 - Crohn's disease: effect of nutrition supplements on Disease Activity Index (CDAI) and nutritional state of the patients in therapy with anti-TNF-alpha and Azathioprine.
Grantee:Júlia Figueiredo Machado
Support type: Scholarships in Brazil - Master