Effects of depression on the cytokine profile in drug naive first-episode psychosis

Author(s):Show less -

Noto, Cristiano ^{[1, 2]} ; Ota, Vanessa Kiyomi ^[3] ; Santoro, Marcos Leite ^[3] ; Ortiz, Bruno B. ^[1] ; Rizzo, Lucas B. ^[1] ; Higuchi, Cinthia Hiroko ^[1] ; Cordeiro, Quirino ^{[1, 2]} ; Belangero, Sintia Iole ^[3] ; Bressan, Rodrigo Affonseca ^[1] ; Gadelha, Ary ^[1] ; Maes, Michael ^{[4, 5, 6]} ; Brietzke, Elisa ^[1]

Affiliation

^[1] Univ Fed Sao Paulo UNIFESP, Dept Psychiat, Sao Paulo - Brazil

^[2] FCMSCSP, Episode Psychosis Program 1, Sao Paulo - Brazil

^[3] Univ Fed Sao Paulo UNIFESP, Dept Morphol & Genet, Div Genet, Sao Paulo - Brazil

^[4] Deakin Univ, Dept Psychiat, Geelong, Vic 3217 - Australia

^[5] Chulalongkorn Univ, Dept Psychiat, Bangkok - Thailand

^[6] State Univ Londrina UEL, Hlth Sci Ctr, Hlth Sci Grad Program, Londrina, PR - Brazil

• Document type: Journal article
• Source: SCHIZOPHRENIA RESEARCH; v. 164, n. 1-3, p. 53-58, MAY 2015.
• Web of Science Citations: 23

Abstract

Schizophrenia is accompanied by alterations in immuno-inflammatory pathways, including abnormalities in cytokine profile. The immune assessment of patients in a first episode of psychosis (FEP) and particularly in drug naive patients is very important to further elucidate this association. The objectives of this study are to delineate the cytokine profile (IL-2, IL-10, IL-4, IL-6, IFN gamma, TNF alpha and IL-17) in FEP patients (n = 55) versus healthy controls (n = 57) and to examine whether the presence of depressive symptoms in FEP is accompanied by a specific cytokine profile. We found increased levels of IL-6, IL-10 and TNFa in FEP patients when compared to healthy controls. FEP patients with depression showed higher IL-4 and TNFa levels versus those without depression. Cytokine levels were not correlated to the total PANSS and the positive or negative subscale scores. Our results suggest that FEP is accompanied by a cytokine profile indicative of monocytic and T regulatory cell (Treg) activation. Depression in FEP is accompanied by monocytic and Th-2 activation, whereas FEP without depression is characterized by Treg activation only. In conclusion, depression emerged as a key component explaining the cytokines imbalance in FEP that is responsible for a large part of the immune-inflammatory abnormalities described. (C) 2015 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 10/08968-6 - Investigation of genetic and epigenetic markers: a translational approach for schizophrenia treatment
• Grantee: Síntia Iole Nogueira Belangero
• Support Opportunities: Regular Research Grants
• FAPESP's process: 11/50740-5 - Prevention in schizophrenia and bipolar disorder from neuroscience to the community: a multiphase, multimodal and translational platform for research and intervention
• Grantee: Rodrigo Affonseca Bressan
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 13/10498-6 - Machine learning in neuroimaging: development of methods and clinical applications in psychiatric disorders
• Grantee: João Ricardo Sato
• Support Opportunities: Regular Research Grants
• FAPESP's process: 10/19176-3 - Gene expression and DNA methylation analysis in drug-naive first episode of psychosis patients
• Grantee: Vanessa Kiyomi Ota Kuniyoshi
• Support Opportunities: Scholarships in Brazil - Doctorate