| Full text | |
| Author(s): |
Machado, K. L. L. L.
[1]
;
Domiciano, D. S.
[1]
;
Machado, L. G.
[1]
;
Lopes, J. B.
[1]
;
Figueiredo, C. P.
[1]
;
Takayama, L.
[1]
;
Oliveira, R. M.
[2]
;
Menezes, P. R.
[3]
;
Pereira, R. M. R.
[1]
Total Authors: 9
|
| Affiliation: | [1] Univ Sao Paulo, Fac Med, Div Rheumatol, Bone Metab Lab, BR-01246903 Sao Paulo, SP - Brazil
[2] RDO Diagnost Med, Sao Paulo - Brazil
[3] Univ Sao Paulo, Fac Med, Dept Prevent Med, BR-01246903 Sao Paulo, SP - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | OSTEOPOROSIS INTERNATIONAL; v. 26, n. 5, p. 1535-1542, MAY 2015. |
| Web of Science Citations: | 3 |
| Abstract | |
A Summary We performed concomitant evaluation of clinical, laboratory, and bone mineral density (BMD) parameters as potential risk factors for falls in a population-based prospective cohort of older adults, since previous studies have focused mostly in clinical risk factors. Loss of hip BMD and persistent hypovitaminosis D were associated with recurrent falls in community-dwelling elderly. Introduction Few studies have performed a concomitant evaluation of clinical data, laboratory bone parameters, and bone mineral density (BMD) to determine more accurately the contribution of each of these variables to risk of falls in elderly persons. We investigated the association between bone parameters and recurrent falls in a population-based prospective cohort of community-dwelling older adults. Methods A total of 705 elderly individuals (448 women, 257 men) were evaluated with clinical data, BMD, and laboratory bone tests at baseline and after a mean follow-up of 4.3 +/- 0.8 years. Individuals with recurrent falls (a parts per thousand yen2 falls in the previous year from the date of the second evaluation) were considered chronic fallers. Logistic regression models were used to identify independent risk factors for recurrent falls. Results The frequency of chronic fallers was 16.5 %. In multivariate analyses, risk factors for recurrent falls were visual impairment (odds ratio (OR) = 2.49, 95 % confidence interval (CI) 1.30-4.74, p = 0.006), use of psychotropic drugs (OR = 2.47, 95 % CI 1.37-4.49, p = 0.003), clinical fracture (OR = 2.78, 95 % CI 1.48-5.20, p = 0.001), persistently low 25-hydroxyvitamin D (25OHD) (< 20 ng/mL) (OR = 1.71, 95 % CI 1.10-2.64, p = 0.016), and loss of total hip BMD during the study (OR = 1.21, 95 % CI 1.17-1.25, p = 0.035 for each 4 % decrease). Conclusions In addition to traditional clinical risk factors for falls, loss of hip BMD and hypovitaminosis D were associated with recurrent falls in community-dwelling elderly persons. Thus, recognizing these factors is essential to preventing falls and improving the outcomes of this population. (AU) | |
| FAPESP's process: | 09/15346-4 - Incidence of vertebral fractures and non-vertebral clinical fractures in a population of individuals aged 65 or more |
| Grantee: | Rosa Maria Rodrigues Pereira |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 03/09313-0 - Prevalence of osteoporosis, vertebral and non-vertebral fractures in a female population aged 65 or older in the Butantã area |
| Grantee: | Rosa Maria Rodrigues Pereira |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 04/12694-8 - Incidence of dementia and cognitive decline in low-income elderly in São Paulo: a cohort study |
| Grantee: | Isabela Judith Martins Bensenor |
| Support Opportunities: | Regular Research Grants |