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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The S6K protein family in health and disease

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Author(s):
Tavares, Mariana R. [1] ; Pavan, Isadora C. B. [1] ; Amaral, Camila L. [1] ; Meneguello, Leticia [2] ; Luchessi, Augusto D. [2] ; Simabuco, Fernando M. [1]
Total Authors: 6
Affiliation:
[1] Univ Estadual Campinas, Sch Appl Sci, Lab Disorders Metab, BR-13484350 Sao Paulo - Brazil
[2] Univ Estadual Campinas, Sch Appl Sci, Biotechnol Lab, BR-13484350 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Review article
Source: Life Sciences; v. 131, p. 1-10, JUN 15 2015.
Web of Science Citations: 70
Abstract

The S6K proteins are mTOR pathway effectors and accumulative evidence suggest that mTOR/S6K signaling contributes to several pathological conditions, such as diabetes, cancer and obesity. The activation of the mTOR/S6K axis stimulates protein synthesis and cell growth. S6K1 has two well-known isoforms, p70-S6K1 and p85-S6K1, generated by alternative translation initiation sites. A third isoform, named p31-S6K1, has been characterized as a truncated type of the protein due to alternative splicing, and reports have shown its important role in cancer. Studies involving S6K2 are scarce. This article aims to review what is new in the literature about these kinases and establish differences regarding their interacting proteins, activation and function, connecting their roles in the homeostasis of the cell and in pathological conditions. (C) 2015 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 14/01386-2 - The role of eukaryotic translation initiation factor 5A (EIF5A) in the translation of s6ks proteins
Grantee:Letícia Meneguello
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 13/22696-7 - Modulation of the S6Ks expression in the central nervous system and their effect in obesity
Grantee:Mariana Rosolen Tavares
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 12/13558-7 - Molecular characterization of S6Ks in obesity and its associated diseases
Grantee:Fernando Moreira Simabuco
Support Opportunities: Research Grants - Young Investigators Grants