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The role of eukaryotic translation initiation factor 5A (eIF5A) in the translation of S6Ks proteins

Grant number: 14/01386-2
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): April 01, 2014
Effective date (End): December 31, 2014
Field of knowledge:Biological Sciences - Biology
Principal Investigator:Augusto Ducati Luchessi
Grantee:Letícia Meneguello
Home Institution: Faculdade de Ciências Aplicadas (FCA). Universidade Estadual de Campinas (UNICAMP). Limeira , SP, Brazil
Associated research grant:10/18095-0 - Study of the eukaryotic translation initiation factor 5A (eIF5A) in mammals, AP.JP

Abstract

The eukaryotic translation initiation factor 5A (EIF5A) protein is highly conserved in eukaryotes. Some studies have shown that eIF5A has important roles in cell proliferation control and HIV-1 replication. EIF5A possesses a particular amino acid residue named hypusine that is not found in others proteins. The hypusine is essential for its activity and is produced by a post-translational modification using spermidine as substrate. Recent studies have demonstrated that EIF5A and the orthologous protein in bacteria (EFP) are involved in the translation of sequences that have three or more consecutive proline residues. Proteins with proline-rich regions are commonly found in prokaryotes and eukaryotes. The S6K2 protein has a region with five consecutives prolines in its C-terminus. The S6Ks proteins are responsible for phosphorylating the ribosomal protein S6 (rpS6) and this activation is essential for protein synthesis and cell cycle progression. Some authors indicate that the proline-rich region may be part of a regulatory mechanism through interactions between proteins, however, there are no reports demonstrating this mechanism for S6K2. In this project will be evaluated the involvement of EIF5A in translation of S6Ks, seeking a greater understanding of this regulation.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PEREIRA, KARINA DANIELLE; TAMBORLIN, LETICIA; MENEGUELLO, LETICIA; GOMES DE PROENCA, ANDRE RICARDO; DE PAULA ANDRADE ALMEIDA, ISADORA CRISTINA; LOURENCO, ROGERIO FERREIRA; LUCHESSI, AUGUSTO DUCATI. Alternative Start Codon Connects eIF5A to Mitochondria. Journal of Cellular Physiology, v. 231, n. 12, p. 2682-2689, DEC 2016. Web of Science Citations: 1.
PAVAN, ISADORA C. B.; YOKOO, SAMI; GRANATO, DANIELA C.; MENEGUELLO, LETICIA; CARNIELLI, CAROLINA M.; TAVARES, MARIANA R.; DO AMARAL, CAMILA L.; DE FREITAS, LIDIA B.; PAES LEME, ADRIANA F.; LUCHESSI, AUGUSTO D.; SIMABUCO, FERNANDO M. Different interactomes for p70-S6K1 and p54-S6K2 revealed by proteomic analysis. PROTEOMICS, v. 16, n. 20, p. 2650-2666, OCT 2016. Web of Science Citations: 6.
TAVARES, MARIANA R.; PAVAN, ISADORA C. B.; AMARAL, CAMILA L.; MENEGUELLO, LETICIA; LUCHESSI, AUGUSTO D.; SIMABUCO, FERNANDO M. The S6K protein family in health and disease. Life Sciences, v. 131, p. 1-10, JUN 15 2015. Web of Science Citations: 70.

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