| Full text | |
| Author(s): |
Jolly, Mohit Kumar
[1, 2]
;
Boareto, Marcelo
[3, 1]
;
Lu, Mingyang
[1]
;
Onuchic, Jose'N
[4, 1, 5, 6]
;
Clementi, Cecilia
[4, 1]
;
Ben-Jacob, Eshel
[1, 5, 7, 8]
Total Authors: 6
|
| Affiliation: | [1] Rice Univ, Ctr Theoret Biol Phys, Houston, TX 77005 - USA
[2] Rice Univ, Dept Bioengn, Houston, TX 77005 - USA
[3] Univ Sao Paulo, Inst Phys, BR-05508 Sao Paulo - Brazil
[4] Rice Univ, Dept Chem, Houston, TX 77005 - USA
[5] Rice Univ, Dept Biosci, Houston, TX 77005 - USA
[6] Rice Univ, Dept Phys & Astron, Houston, TX 77005 - USA
[7] Tel Aviv Univ, Sch Phys & Astron, IL-69978 Tel Aviv - Israel
[8] Tel Aviv Univ, Sagol Sch Neurosci, IL-69978 Tel Aviv - Israel
Total Affiliations: 8
|
| Document type: | Journal article |
| Source: | NEW JOURNAL OF PHYSICS; v. 17, MAY 20 2015. |
| Web of Science Citations: | 12 |
| Abstract | |
Notch pathway is an evolutionarily conserved cell-cell communication mechanism governing cell-fate during development and tumor progression. It is activated when Notch receptor of one cell binds to either of its ligand-Delta or Jagged-of another cell. Notch-Delta (ND) signaling forms a two-way switch, and two cells interacting via ND signaling adopt different fates-Sender (high ligand, low receptor) and Receiver (low ligand, high receptor). Notch-Delta-Jagged signaling (NDJ) behaves as a three-way switch and enables an additional fate-hybrid Sender/Receiver (S/R) (medium ligand, medium receptor). Here, by extending our framework of NDJ signaling for a two-cell system, we show that higher production rate of Jagged, but not that of Delta, expands the range of parameters for which both cells attain the hybrid S/R state. Conversely, glycosyltransferase Fringe and cis-inhibition reduces this range of conditions, and reduces the relative stability of the hybrid S/R state, thereby promoting cell-fate divergence and consequently lateral inhibition-based patterns. Lastly, soluble Jagged drives the cells to attain the hybrid S/R state, and soluble Delta drives them to be Receivers. We also discuss the critical role of hybrid S/R state in promoting cancer metastasis by enabling collective cell migration and expanding cancer stem cell (CSC) population. (AU) | |
| FAPESP's process: | 13/14438-8 - Study of gene regulatory network by stochastic methods and statistical mechanics |
| Grantee: | Marcelo Boareto Do Amaral |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate (Direct) |