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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Evidence of epithelial-mesenchymal transition in canine prostate cancer metastasis

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Author(s):
Fonseca-Alves, Carlos Eduardo [1] ; Kobayashi, Priscila Emiko [1] ; Rivera-Calderon, Luis Gabriel [1] ; Laufer-Amorim, Renee [1]
Total Authors: 4
Affiliation:
[1] Univ Estadual Paulista UNESP, Dept Vet Clin, Sch Vet Med & Anim Sci, BR-18618970 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Research in Veterinary Science; v. 100, p. 176-181, JUN 2015.
Web of Science Citations: 7
Abstract

The epithelial mesenchymal transition (EMT) is a fundamental event responsible for the invasiveness and metastasis of epithelial tumours. The EMT has been described in many human cancers, but there are few reports of this phenomenon in veterinary oncology. Due to the importance of this process, the current study evaluated mesenchymal and epithelial marker protein expression in prostate lesions from dogs. Our results indicate both a loss of E-cadherin and translocation of P-catenin from the membrane to the cytoplasm and nucleus in the tumour group. Vimentin expression in the tumour group was higher than in normal tissue. All of the metastases were positive for prostate-specific antigen, pan-cytokeratin and E-cadherin, although fewer positive cells were present than in the primary tumours. The immunohistochemical results showed a loss of epithelial markers and a gain of a mesenchymal marker among metastatic cells, suggesting that the EMT occurs during the metastatic process of canine prostate carcinoma. (C) 2015 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 10/13774-6 - Imunohistochemistry evaluation of c-Myc and NKX3.1 in tissue microarray (TMA) in pre-neoplastic and neoplastic lesions in canine prostate
Grantee:Carlos Eduardo Fonseca Alves
Support type: Scholarships in Brazil - Master
FAPESP's process: 12/16068-0 - Epigenetic evaluation of NKX3.1 and CDH1 and immunohistochemistry expression of c-myc, NKX3.1 and E-cadherin on tissue microarray (TMA) of pre-neoplastic and neoplastic prostate of dogs
Grantee:Renee Laufer Amorim
Support type: Regular Research Grants