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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Antitrypanosomal Acetylene Fatty Acid Derivatives from the Seeds of Porcelia macrocarpa (Annonaceae)

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Santos, Luciana de A. [1] ; Cavalheiro, Alberto J. [1] ; Tempone, Andre G. [2] ; Correa, Daniela S. [2] ; Alexandre, Tatiana R. [2] ; Quintiliano, Natalia F. [3] ; Rodrigues-Oliveira, Andre F. [3] ; Oliveira-Silva, Diogo [3] ; Martins, Roberto Carlos C. [4] ; Lago, Joao Henrique G. [3]
Total Authors: 10
[1] Univ Estadual Paulista, Inst Quim, Nucleo Bioensaios Biossintese & Ecofisiol Prod Na, BR-14800060 Araraquara, SP - Brazil
[2] Adolfo Lutz Inst, Ctr Parasitol & Micol, BR-01246902 Sao Paulo, SP - Brazil
[3] Univ Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, BR-09972270 Diadema, SP - Brazil
[4] Univ Fed Rio de Janeiro, Inst Pesquisa Prod Nat, BR-21941902 Rio De Janeiro, RJ - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Molecules; v. 20, n. 5, p. 8168-8180, MAY 2015.
Web of Science Citations: 4

Chagas' disease is caused by a parasitic protozoan and affects the poorest population in the world, causing high mortality and morbidity. As a result of the toxicity and long duration of current treatments, the discovery of novel and more efficacious drugs is crucial. In this work, the hexane extract from seeds of Porcelia macrocarpa R.E. Fries (Annonaceae) displayed in vitro antitrypanosomal activity against trypomastigote forms of T. cruzi by the colorimetric MTT assay (IC50 of 65.44 g/mL). Using chromatographic fractionation over SiO2, this extract afforded a fraction composed by one active compound (IC50 of 10.70 mu g/mL), which was chemically characterized as 12,14-octadecadiynoic acid (macrocarpic acid). Additionally, two new inactive acetylene compounds (,'-dimacro-carpoyl--oleylglycerol and -macrocarpoyl-'-oleylglycerol) were also isolated from the hexane extract. The complete characterization of the isolated compounds was performed by analysis of NMR and MS data as well as preparation of derivatives. (AU)

FAPESP's process: 11/51739-0 - Sustainable use of biodiversity in Atlantic Forest remnants in São Paulo: evaluation, isolation and molecular characterization of bioactive secondary metabolites in plant species
Grantee:João Henrique Ghilardi Lago
Support type: BIOTA-FAPESP Program - Regular Research Grants
FAPESP's process: 12/18756-1 - Evaluation of novel alternative therapies with synthetic drugs using in vitro and experimental models of Leishmania (L.) infantum chagasi
Grantee:André Gustavo Tempone Cardoso
Support type: Regular Research Grants