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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Development of a pharmacogenetic-based warfarin dosing algorithm and its performance in Brazilian patients: highlighting the importance of population-specific calibration

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Author(s):
Junior Lima Santos, Paulo Caleb [1] ; Marcatto, Leiliane Rodrigues [1] ; Duarte, Nubia Esteban [1] ; Gadi Soares, Renata Alonso [1] ; Cassaro Strunz, Celia Maria [2] ; Scanavacca, Maurcio [3] ; Krieger, Jose Eduardo [1] ; Pereira, Alexandre Costa [1]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Sch Med, Heart Inst InCor, Lab Genet & Mol Cardiol, BR-05403000 Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Med, Heart Inst InCor, Clin Lab, BR-05403000 Sao Paulo - Brazil
[3] Univ Sao Paulo, Sch Med, Heart Inst InCor, Clin Cardiol Div, BR-05403000 Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: PHARMACOGENOMICS; v. 16, n. 8, p. 865-876, 2015.
Web of Science Citations: 14
Abstract

Background: The main aims of the present study were to develop a pharmacogenetic-based warfarin dosing algorithm and to validate it in a highly admixed population. Materials \& methods: We included two patient cohorts treated with warfarin (first cohort, n = 832; and second cohort, n = 133). Results: Our algorithm achieved a determination coefficient of 40% including the variables age, gender, weight, height, self-declared race, amiodarone use, enzyme inducers use, VKORC1 genotypes and predicted phenotypes according to CYP2C9 polymorphisms. Conclusion: Data suggest that our developed algorithm is more accurate than the IWPC algorithm when the application is focused on patients from the Brazilian population. Population-specific derivation and/or calibration of warfarin dosing algorithms may lead to improved performance compared with general use dosing algorithms currently available. (AU)

FAPESP's process: 13/20614-3 - Pharmacogenetic analyses for cardiovascular drugs focusing on implementation
Grantee:Paulo Caleb Júnior de Lima Santos
Support Opportunities: Scholarships in Brazil - Young Researchers
FAPESP's process: 13/09295-3 - Pharmacogenetic of cardiovascular system drugs focusing on implementation
Grantee:Paulo Caleb Júnior de Lima Santos
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 12/00316-5 - Mixed Models in Genetic mapping using Family-Based Designs and platforms of SNPs
Grantee:Nubia Esteban Duarte
Support Opportunities: Scholarships in Brazil - Post-Doctoral