Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Development of a pharmacogenetic-based warfarin dosing algorithm and its performance in Brazilian patients: highlighting the importance of population-specific calibration

Full text
Author(s):
Junior Lima Santos, Paulo Caleb [1] ; Marcatto, Leiliane Rodrigues [1] ; Duarte, Nubia Esteban [1] ; Gadi Soares, Renata Alonso [1] ; Cassaro Strunz, Celia Maria [2] ; Scanavacca, Maurcio [3] ; Krieger, Jose Eduardo [1] ; Pereira, Alexandre Costa [1]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Sch Med, Heart Inst InCor, Lab Genet & Mol Cardiol, BR-05403000 Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Med, Heart Inst InCor, Clin Lab, BR-05403000 Sao Paulo - Brazil
[3] Univ Sao Paulo, Sch Med, Heart Inst InCor, Clin Cardiol Div, BR-05403000 Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: PHARMACOGENOMICS; v. 16, n. 8, p. 865-876, 2015.
Web of Science Citations: 14
Abstract

Background: The main aims of the present study were to develop a pharmacogenetic-based warfarin dosing algorithm and to validate it in a highly admixed population. Materials \& methods: We included two patient cohorts treated with warfarin (first cohort, n = 832; and second cohort, n = 133). Results: Our algorithm achieved a determination coefficient of 40% including the variables age, gender, weight, height, self-declared race, amiodarone use, enzyme inducers use, VKORC1 genotypes and predicted phenotypes according to CYP2C9 polymorphisms. Conclusion: Data suggest that our developed algorithm is more accurate than the IWPC algorithm when the application is focused on patients from the Brazilian population. Population-specific derivation and/or calibration of warfarin dosing algorithms may lead to improved performance compared with general use dosing algorithms currently available. (AU)

FAPESP's process: 13/20614-3 - Pharmacogenetic analyses for cardiovascular drugs focusing on implementation
Grantee:Paulo Caleb Júnior de Lima Santos
Support type: Scholarships in Brazil - Young Researchers
FAPESP's process: 13/09295-3 - Pharmacogenetic of cardiovascular system drugs focusing on implementation
Grantee:Paulo Caleb Júnior de Lima Santos
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 12/00316-5 - Mixed Models in Genetic mapping using Family-Based Designs and platforms of SNPs
Grantee:Nubia Esteban Duarte
Support type: Scholarships in Brazil - Post-Doctorate