| Full text | |
| Author(s): |
Junior Lima Santos, Paulo Caleb
[1]
;
Marcatto, Leiliane Rodrigues
[1]
;
Duarte, Nubia Esteban
[1]
;
Gadi Soares, Renata Alonso
[1]
;
Cassaro Strunz, Celia Maria
[2]
;
Scanavacca, Maurcio
[3]
;
Krieger, Jose Eduardo
[1]
;
Pereira, Alexandre Costa
[1]
Total Authors: 8
|
| Affiliation: | [1] Univ Sao Paulo, Sch Med, Heart Inst InCor, Lab Genet & Mol Cardiol, BR-05403000 Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Med, Heart Inst InCor, Clin Lab, BR-05403000 Sao Paulo - Brazil
[3] Univ Sao Paulo, Sch Med, Heart Inst InCor, Clin Cardiol Div, BR-05403000 Sao Paulo - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | PHARMACOGENOMICS; v. 16, n. 8, p. 865-876, 2015. |
| Web of Science Citations: | 14 |
| Abstract | |
Background: The main aims of the present study were to develop a pharmacogenetic-based warfarin dosing algorithm and to validate it in a highly admixed population. Materials \& methods: We included two patient cohorts treated with warfarin (first cohort, n = 832; and second cohort, n = 133). Results: Our algorithm achieved a determination coefficient of 40% including the variables age, gender, weight, height, self-declared race, amiodarone use, enzyme inducers use, VKORC1 genotypes and predicted phenotypes according to CYP2C9 polymorphisms. Conclusion: Data suggest that our developed algorithm is more accurate than the IWPC algorithm when the application is focused on patients from the Brazilian population. Population-specific derivation and/or calibration of warfarin dosing algorithms may lead to improved performance compared with general use dosing algorithms currently available. (AU) | |
| FAPESP's process: | 13/20614-3 - Pharmacogenetic analyses for cardiovascular drugs focusing on implementation |
| Grantee: | Paulo Caleb Júnior de Lima Santos |
| Support Opportunities: | Scholarships in Brazil - Young Researchers |
| FAPESP's process: | 13/09295-3 - Pharmacogenetic of cardiovascular system drugs focusing on implementation |
| Grantee: | Paulo Caleb Júnior de Lima Santos |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 12/00316-5 - Mixed Models in Genetic mapping using Family-Based Designs and platforms of SNPs |
| Grantee: | Nubia Esteban Duarte |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |