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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Anthelmintic Effects of the Essential Oil of Fennel (Foeniculum vulgare Mill., Apiaceae) against Schistosoma mansoni

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Author(s):
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Wakabayashi, Kamila A. L. [1] ; de Melo, Nathalya I. [1] ; Aguiar, Daniela P. [1] ; de Oliveira, Pollyanna F. [1] ; Groppo, Milton [2] ; da Silva Filho, Ademar A. [3] ; Rodrigues, Vanderlei [4] ; Cunha, Wilson R. [1] ; Tavares, Denise C. [1] ; Magalhaes, Lizandra G. [1] ; Crotti, Antonio E. M. [5, 1]
Total Authors: 11
Affiliation:
[1] Univ Franca, Nucleo Pesquisas Ciencias Exatas & Tecnol, Franca, SP - Brazil
[2] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Biol, BR-14049 Ribeirao Preto, SP - Brazil
[3] Univ Fed Juiz de Fora, Fac Farm, Juiz De Fora, MG - Brazil
[4] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Bioquim & Imunol, BR-14049 Ribeirao Preto, SP - Brazil
[5] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Quim, BR-14049 Ribeirao Preto, SP - Brazil
Total Affiliations: 5
Document type: Journal article
Source: CHEMISTRY & BIODIVERSITY; v. 12, n. 7, p. 1105-1114, JUL 2015.
Web of Science Citations: 11
Abstract

Foeniculum vulgareMill. (Apiaceae), known as fennel, is a widespread aromatic herbaceous plant, and its essential oil is used as additive in the food, pharmaceutical, cosmetic, and perfume industries. The in vitro antischistosomal activity and cytotoxic effects against V79 cells of the essential oil of F. vulgare cultivated in southeastern Brazil (FV-EO) was investigated. The FV-EO was obtained by hydrodistillation and characterized by GC-FID and GC/MS analyses. (E)-Anethole (69.8%) and limonene (22.5%) were identified as the major constituents. Its anthelmintic activity against Schistosoma mansoni was evaluated at concentrations of 10, 50, and 100g/ml, and it was found to be active against adult S. mansoni worms, although it was less effective than the positive control praziquantel (PZQ) in terms of separation of the coupled pairs, mortality, and decreased motor activity. However, FV-EO elicited an interesting dose-dependent reduction in the number of S. mansoni eggs. On their own, (E)-anethole and the limonene enantiomers were much less effective than FV-EO and PZQ. An XTT-cytotoxicity-based assay evidenced no FV-EO cytotoxicity against V79 cells. In summary, FV-EO displayed moderate in vitro schistosomicidal activity against adult S. mansoni worms, exerted remarkable inhibitory effects on the egg development, and was of low toxicity. (AU)

FAPESP's process: 11/05732-4 - Study of cytotoxic and genotoxic potential of Solanum lycocarpum and their majoritary compounds and their influence on genotoxicity induced by different mutagens
Grantee:Denise Crispim Tavares Barbosa
Support Opportunities: Regular Research Grants
FAPESP's process: 09/15207-4 - Evaluation of the effect of lignans and neolignans on Schistosoma mansoni: a proteomic study
Grantee:Lizandra Guidi Magalhães
Support Opportunities: Scholarships in Brazil - Post-Doctoral