Oxidative stress in entomopathogenic fungi grown on insect-like hydrocarbons

Author(s)

Huarte-Bonnet, Carla ^[1] ; Patricia Juarez, M. ^[1] ; Pedrini, Nicolas ^[1]

Affiliation

^[1] Inst Invest Bioquim La Plata CCT La Plata CONICET, Fac Ciencias Med, La Plata - Argentina

• Document type: Journal article
• Source: CURRENT GENETICS; v. 61, n. 3, p. 289-297, AUG 2015.
• Web of Science Citations: 18

Abstract

Entomopathogenic fungi mostly attack their insect hosts by penetration through the cuticle. The outermost insect surface is covered by a lipid-rich layer, usually composed of very long chain hydrocarbons. These fungi are apt to grow on straight chain hydrocarbons (alkanes) as the sole carbon source. Insect-like hydrocarbons are first hydroxylated by a microsomal P450 monooxygenase system, and then fully catabolized by peroxisomal beta-oxidation reactions in Beauveria bassiana. In this review, we will discuss lipid metabolism adaptations in alkane-grown fungi, and how an oxidative stress scenario is established under these conditions. Fungi have to pay a high cost for hydrocarbon utilization; high levels of reactive oxygen species are produced and a concomitant antioxidant response is triggered in fungal cells to cope with this drawback. (AU)

• FAPESP's process: 14/01229-4 - International Symposium on Fungal Stress - ISFUS
• Grantee: Drauzio Eduardo Naretto Rangel
• Support Opportunities: Organization Grants - Scientific Meeting