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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Carotid body overactivity induces respiratory neurone channelopathy contributing to neurogenic hypertension

Full text
Author(s):
Moraes, Davi J. A. [1] ; Machado, Benedito H. [1] ; Paton, Julian F. R. [2]
Total Authors: 3
Affiliation:
[1] Univ Sao Paulo, Dept Physiol, Sch Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP - Brazil
[2] Univ Bristol, Bristol Cardio Vasc, Sch Physiol & Pharmacol, Bristol BS8 1TD, Avon - England
Total Affiliations: 2
Document type: Review article
Source: JOURNAL OF PHYSIOLOGY-LONDON; v. 593, n. 14, p. 3055-3063, JUL 15 2015.
Web of Science Citations: 14
Abstract

Why sympathetic activity rises in neurogenic hypertension remains unknown. It has been postulated that changes in the electrical excitability of medullary pre-sympathetic neurones are the main causal mechanism for the development of sympathetic overactivity in experimental hypertension. Here we review recent data suggesting that enhanced sympathetic activity in neurogenic hypertension is, at least in part, dependent on alterations in the electrical excitability of medullary respiratory neurones and their central modulation of sympatho-excitatory networks. We also present results showing a critical role for carotid body tonicity in the aetiology of enhanced central respiratory modulation of sympathetic activity in neurogenic hypertension. We propose a novel hypothesis of respiratory neurone channelopathy induced by carotid body overactivity in neurogenic hypertension that may contribute to sympathetic excess. Moreover, our data support the notion of targeting the carotid body as a potential novel therapeutic approach for reducing sympathetic vasomotor tone in neurogenic hypertension. (AU)

FAPESP's process: 13/06077-5 - Changes in the neural networks involved with the generation and control of sympathetic and respiratory activities in different experimental models of hypoxia
Grantee:Benedito Honorio Machado
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 13/10484-5 - Electrophysiological and molecular characterization of neurons involved in the generation of respiratory rhythm and pattern of rats during postnatal development
Grantee:Davi José de Almeida Moraes
Support Opportunities: Research Grants - Young Investigators Grants