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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

They Must Hold Tight: Junction Proteins, Microbiota And Immunity In Intestinal Mucosa

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Author(s):
Castoldi, Angela [1] ; de Aguiar, Cristhiane Favero [1] ; Moraes-Vieira, Pedro Manoel [2] ; Saraiva Camara, Niels Olsen [3, 1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Dept Imunol, BR-05508900 Sao Paulo, SP - Brazil
[2] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Endocrinol Metab & Diabet, Boston, MA 02205 - USA
[3] Univ Fed Sao Paulo, Dept Med, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Review article
Source: CURRENT PROTEIN & PEPTIDE SCIENCE; v. 16, n. 7, p. 655-671, 2015.
Web of Science Citations: 9
Abstract

Homeostasis of the immune system depends on several factors. The gastrointestinal tract plays an important role in maintaining our immune system. With this aim, the intestinal immune system interacts with epithelial barrier molecules, especially tight junction proteins, that are key molecules involved in controlling paracellular permeability to increase the protection barrier against external antigens or possibly to respond to commensal microorganisms. During intestinal inflammatory diseases, the expression of innate immune receptors in intestinal epithelial cells and infiltration of immune cells are related, but it is still unclear how the immune system induces modulation of paracellular permeability. In this review, we provide an overview of the understanding of how the immune system modulates the expression of tight junctions to maintain the mucosal immune system. (AU)

FAPESP's process: 11/15682-4 - Sepsis and obesity: study of the relationship between obesity and immune regulation in an experimental model of sepsis
Grantee:Angela Castoldi
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 14/02218-6 - A study of the signaling pathways induced by RBP4 in macrophages and dendritic cells in obesity-induced insulin resistance
Grantee:Angela Castoldi
Support type: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 12/16794-3 - Influence of gut microbiota on NKT cells profile in an experimental model of colitis
Grantee:Cristhiane Favero de Aguiar
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 12/02270-2 - New cellular, molecular and immunological mechanisms involved in acute and chronic renal injury: the search for new therapeutical approaches
Grantee:Niels Olsen Saraiva Câmara
Support type: Research Projects - Thematic Grants
FAPESP's process: 14/10828-9 - Function of intestinal lamina propria NKT cells
Grantee:Cristhiane Favero de Aguiar
Support type: Scholarships abroad - Research Internship - Doctorate