Digital vertebral morphometry performed by DXA: a valuable opportunity for identifying fractures during bone mass assessment

Author(s)

Muszkat, Patricia ^[1] ; Rodrigues Camargo, Marilia Brasilio ^[1] ; Emo Peters, Barbara Santarosa ^[2] ; Kunii, Ilda Sizue ^[1] ; Lazaretti-Castro, Marise ^[1]

Affiliation

^[1] Fed Univ Sao Paulo Unifesp, Sch Med, Div Endocrinol, Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Fac Publ Hlth, Dept Nutr, Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: Arquivos Brasileiros de Endocrinologia e Metabologia; v. 59, n. 2, p. 98-104, APR 2015.
• Web of Science Citations: 4

Abstract

Objectives: To evaluate the usefulness of vertebral morphometry in identifying unreferred vertebral fractures and correlate potential risk factors. Subjects and methods: Female patients above 45 years, postmenopausal for at least 2 years, diagnosed with osteoporosis and undergoing treatment for at least three months were considered eligible. All of them underwent bone densitometry and vertebral morphometry performed by concomitant DXA. The presence of fractures was defined between T7 and L4; only moderate and severe fractures were considered for analysis. All volunteers were submitted to laboratory tests, anthropometry and responded a questionnaire on their lifestyle habits and medical history. Results: Thirty two (17%) out of the 188 female patients presented with at least one vertebral fracture, among whom only 4 (12.5%) were previously aware of the fracture. The fractures were mainly located on the thoracic spine. Nine patients had severe fractures (28.1%), whereas 23 had moderate fractures (71.9%). On average, patients with fractures were 5 years older and weighed 5 kilograms less than those without fractures. The creatinine clearance was on average 9 mL/min less in patients with vertebral fracture. The assessment of vertebral fractures by morphometry is a fast, accurate and complementary method associated with low radiation exposure for identifying moderate and severe vertebral fractures. Predisposition to vertebral fractures does not depend solely on BMD. (AU)

• FAPESP's process: 08/55567-7 - Vitamin D status in patients with Osteoporosis treated in the ambulatory of bone metabolic diseases at a university hospital in the city of São Paulo and evaluation of intestinal calcium absorption
• Grantee: Marise Lazaretti Castro
• Support Opportunities: Regular Research Grants