Neuroimaging in Sensory Neuronopathy

Author(s)

Casseb, Raphael Fernandes ^[1] ; Muro Martinez, Alberto Rolim ^[1] ; Ribeiro de Paiva, Jean Levi ^[1] ; Franca, Marcondes Cavalcante ^[1]

Affiliation

^[1] Univ Estadual Campinas, Sch Med, Neuroimaging Lab, BR-13083970 Campinas, SP - Brazil

• Document type: Journal article
• Source: JOURNAL OF NEUROIMAGING; v. 25, n. 5, p. 704-709, SEP-OCT 2015.
• Web of Science Citations: 7

Abstract

Sensory neuronopathies (SN) are a group of disorders characterized by primary damage to the dorsal root ganglia neurons. Clinical features include multifocal areas of hypoaesthesia, pain, dysautonomia, and sensory ataxia, which is the major source of disability. Diagnosis relies upon clinical assessment and nerve conductions studies, but sometimes it is difficult to distinguish SN from similar conditions, such as axonal polyneuropathies and some myelopathies. In this scenario, underdiagnosis is certainly an important issue for SN patients and additional diagnostic tools are needed. MRI is able to evaluate the dorsal columns of the spinal cord and has proven useful in the workup of SN patients. Although T2 weighted hyperintensity restricted to the posterior fasciculi without contrast enhancement is the typical finding, additional abnormalities have been recently reported. The aim of this review is to gather available information on neuroimaging findings of SN, discuss their clinical correlates and the potential impact of novel MRI-based techniques. (AU)

• FAPESP's process: 13/01766-7 - Sensory neuronopathies: investigation of new diagnostic methods, mechanisms of the disease and therapeutic strategies
• Grantee: Marcondes Cavalcante Franca Junior
• Support Opportunities: Research Grants - Young Investigators Grants