| Full text | |
| Author(s): |
Balardin, Joana B.
[1, 2]
;
Batistuzzo, Marcelo C.
[2]
;
Moraes Martin, Maria da Graca
[2]
;
Sato, Joao R.
[3]
;
Smid, Jerusa
[1]
;
Porto, Claudia
[1]
;
Savage, Cary R.
[4]
;
Nitrini, Ricardo
[1]
;
Amaro, Jr., Edson
[2]
;
Miotto, Eliane C.
[1]
Total Authors: 10
|
| Affiliation: | [1] Univ Sao Paulo, Fac Med, Dept Neurol, BR-05403001 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Fac Med, Dept Radiol, BR-05403001 Sao Paulo, SP - Brazil
[3] Univ Fed ABC, Ctr Matemat Comp & Cognicao, Santo Andre - Brazil
[4] Univ Kansas, Dept Psychiat & Behav Sci, Ctr Hlth Behav Neurosci, Kansas City, KS - USA
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | FRONTIERS IN AGING NEUROSCIENCE; v. 7, AUG 4 2015. |
| Web of Science Citations: | 6 |
| Abstract | |
In this study we examined differences in fMRI activation and deactivation patterns during episodic verbal memory encoding between individuals with MCI (n = 18) and healthy controls (HCs) (n = 17). Participants were scanned in two different sessions during the application of self-initiated or directed instructions to apply semantic strategies at encoding of word lists. MCI participants showed reduced free recall scores when using self-initiated encoding strategies that were increased to baseline controls' level after directed instructions were provided. During directed strategic encoding, greater recruitment of frontoparietal regions was observed in both MCI and control groups; group differences between sessions were observed in the ventromedial prefrontal cortex and the right superior frontal gyrus. This study provides evidence suggesting that differences of activity in these regions may be related to encoding deficits in MCI, possibly mediating executive functions during task performance. (AU) | |
| FAPESP's process: | 09/09924-5 - An fMRI investigation of semantic cognitive training on episodic memory in patients with mCi |
| Grantee: | Joana Bisol Balardin |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 05/56464-9 - Neuroscience Imaging Center at University of São Paulo Medical School |
| Grantee: | Giovanni Guido Cerri |
| Support Opportunities: | Inter-institutional Cooperation in Support of Brain Research (CINAPCE) - Thematic Grants |