Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Gut Bacteria Products Prevent AKI Induced by Ischemia-Reperfusion

Full text
Show less -
Andrade-Oliveira, Vinicius [1] ; Amano, Mariane T. [1] ; Correa-Costa, Matheus [1] ; Castoldi, Angela [1] ; Felizardo, Raphael J. F. [2] ; de Almeida, Danilo C. [2] ; Bassi, Enio J. [1] ; Moraes-Vieira, Pedro M. [1] ; Hiyane, Meire I. [1] ; Rodas, Andrea C. D. [1] ; Peron, Jean P. S. [3] ; Aguiar, Cristhiane F. [1] ; Reis, Marlene A. [4] ; Ribeiro, Willian R. [5] ; Valduga, Claudete J. [5] ; Curi, Rui [6] ; Ramirez Vinolo, Marco Aurelio [7] ; Ferreira, Caroline M. [6] ; Saraiva Camara, Niels Olsen [2, 1]
Total Authors: 19
[1] Univ Sao Paulo, Lab Transplantat Immunobiol, Dept Immunol, Inst Biomed Sci 4, BR-05508000 Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Div Nephrol, Sao Paulo - Brazil
[3] Univ Sao Paulo, Neuroimmune Interact Lab, Dept Immunol, Inst Biomed Sci 4, BR-05508000 Sao Paulo - Brazil
[4] Univ Fed Triangulo Mineiro, Dept Pathol, Uberaba - Brazil
[5] Univ Anhanguera Sao Paulo UNIAN SP, Dept Pharm & Biotechnol, Sao Paulo - Brazil
[6] Univ Sao Paulo, Dept Physiol & Biophys, Inst Biomed Sci 4, BR-05508000 Sao Paulo - Brazil
[7] Univ Campinas UNICAMP, Inst Biol, Dept Genet Evolut & Bioagents, Sao Paulo - Brazil
Total Affiliations: 7
Document type: Journal article
Source: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY; v. 26, n. 8, p. 1877-1888, AUG 2015.
Web of Science Citations: 86

Short-chain fatty acids (SCFAs) are fermentation end products produced by the intestinal nnicrobiota and have anti-inflammatory and histone deacetylase inhibiting properties. Recently, a dual relationship between the intestine and kidneys has been unraveled. Therefore, we evaluated the role of SCFA in an AKI model in which the inflammatory process has a detrimental role. We observed that therapy with the three main SCFAs (acetate, propionate, and butyrate) improved renal dysfunction caused by injury. This protection was associated with low levels of local and systemic inflammation, oxidative cellular stress, cell infiltration/activation, and apoptosis. However, it was also associated with an increase in autophagy. Moreover, SCFAs inhibited histone deacetylase activity and modulated the expression levels of enzymes involved in chromatin modification. In vitro analyses showed that SCFAs modulated the inflammatory process, decreasing the maturation of dendritic cells and inhibiting the capacity of these cells to induce CD4(+) and CD8(+) T cell proliferation. Furthermore, SCFAs ameliorated the effects of hypoxia in kidney epithelial cells by improving mitochondria! biogenesis. Notably, mice treated with acetate-producing bacteria also had better outcomes after AKI. Thus, we demonstrate that SCFAs improve organ function and viability after an injury through modulation of the inflammatory process, most likely via epigenetic modification. (AU)

FAPESP's process: 12/02270-2 - New cellular, molecular and immunological mechanisms involved in acute and chronic renal injury: the search for new therapeutical approaches
Grantee:Niels Olsen Saraiva Câmara
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 11/01016-2 - Short Chain Fatty Acid as modulators of the inflammatory response in chronic and acute experimental kidney injuries
Grantee:Vinicius de Andrade Oliveira
Support Opportunities: Scholarships in Brazil - Doctorate