Systematic review of the efficacy in seizure control and safety of neuronavigation in epilepsy surgery: The need for well-designed prospective studies

Author(s):Show less -

Sonvenso, Daniele Kanashiro ^{[1, 2]} ; Itikawa, Emerson Nobuyuki ^{[1, 2, 3]} ; Santos, Marcelo Volpon ^[4] ; Santos, Leonardo Alexandre ^{[1, 2]} ; Trevisan, Ana Carolina ^{[1, 2, 3]} ; Bianchin, Marino Muxfeldt ^[5] ; Pitella, Felipe Arriva ^{[1, 2]} ; Kato, Mery ^{[1, 2]} ; Carlotti, Jr., Carlos Gilberto ^{[4, 5]} ; Filho Busatto, Geraldo ^[6] ; Velasco, Tonicarlo Rodrigues ^[5] ; Santos, Antonio Carlos ^{[1, 6, 2]} ; Leite, Joao Pereira ^[5] ; Sakamoto, Americo Ceiki ^[5] ; Machado, Helio Rubens ^{[4, 5]} ; Nunes, Altacilio Aparecido ^[7] ; Wichert-Ana, Lauro ^{[1, 6, 2, 7, 3]}

Affiliation

^[1] Univ Sao Paulo, BR-14049 Ribeirao Preto - Brazil

^[2] Univ Sao Paulo, Image Sci & Med Phys Ctr, Nucl Med & Mol Imaging Sect, Dept Internal Med, BR-14049 Ribeirao Preto - Brazil

^[3] Univ Sao Paulo, Sao Carlos Sch Engn, Bioengn Interunits Program, Sao Carlos, SP - Brazil

^[4] Univ Sao Paulo, Dept Surg & Anat, Clin Surg Postgrad Program, BR-14049 Ribeirao Preto - Brazil

^[5] Univ Sao Paulo, Ribeirao Preto Sch Med, Epilepsy Surg Ctr CIREP, BR-14049 Ribeirao Preto - Brazil

^[6] Univ Sao Paulo, NAPNA, Ctr Interdisciplinary Res Appl Neurosci, BR-05508 Sao Paulo - Brazil

^[7] Univ Sao Paulo, Clin Hosp, Hlth Technol Assessment Ctr, BR-14049 Ribeirao Preto - Brazil

• Document type: Review article
• Source: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY; v. 31, p. 99-107, SEP 2015.
• Web of Science Citations: 2

Abstract

Purpose: To evaluate the efficacy of surgery with neuronavigation compared to conventional neurosurgical treatment of epilepsy in terms of safety and seizure outcomes and to assess the quality of the evidence base of neuronavigation in this clinical context. Method: Systematic review using the electronic databases of Cochrane, CRD, PubMed, Embase, SciELO and LILACS in Portuguese, English and Spanish. The {[}MeSF11 terms included ``epilepsy{''} and ``neuronavigation{''}. Eligibility Criteria: Studies assessing surgery with neuronavigation for the surgical treatment of epilepsy or brain injuries associated with epileptic seizures. Results: We identified 28 original articles. All articles yielded scientific evidence of low quality. Outcome data presented in the articles identified was heterogeneous and did not amount to compelling evidence that epilepsy surgery with neuronavigation produces higher rates of seizure control, a reduced need for reoperations, or lower rates of complications or postoperative neurological deficits. Conclusion: We were unable to find any publications providing convincing evidence that neuronavigation improves outcomes of epilepsy surgery. Whilst this does not mean that neuronavigation cannot improve neurosurgical outcomes in this clinical setting, well-designed research studies evaluating the role of neuronavigation are urgently needed. (C) 2015 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved. (AU)

• FAPESP's process: 12/50329-6 - Translational neuroscience of Alzheimer's disease: preclinical and clinical studies of b-amyloid peptide and other biomarkers
• Grantee: Geraldo Busatto Filho
• Support Opportunities: Research Projects - Thematic Grants