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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effects of beta-(1 -> 3,1 -> 6)-D-glucan and density of diets on the blood profiles of immunologically challenged weaned piglets

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Saleh, Mayra A. D. [1] ; Amorim, Alessandro B. [2] ; Grecco, Henrique A. T. [1] ; Berto, Dirlei A. [1] ; Padovani, Carlos R. [3] ; Orsi, Ricardo de O. [1] ; Tse, Marcos L. P. [1]
Total Authors: 7
[1] UNESP Sao Paulo State Univ, Fac Vet Med & Anim Sci, Dept Anim Prod, BR-18618970 Sao Paulo - Brazil
[2] Univ Fed Mato Grosso, Inst Agr Sci & Technol, BR-78735902 Campo Grande, MS - Brazil
[3] UNESP Sao Paulo State Univ, Biosci Inst, Dept Biostat, BR-18618970 Campo Grande, MS - Brazil
Total Affiliations: 3
Document type: Journal article
Source: International Journal of Biological Macromolecules; v. 80, p. 659-667, SEP 2015.
Web of Science Citations: 2

An experiment was conducted to evaluate the effects of two levels of the beta-(1 -> 3,1 -> 6)-D-glucan (0 and 500 ppm) from yeast Saccharomyces cerevisiae and two levels of energy (3300 and 3450 kcal ME kg(-1)) on the hematological, immunological and, biochemical profiles of thirty-six 21-days-old weaned piglets, challenged with 150 mu g kg(-1) of BW lipopolysaccharide (LPS) from Escherichia coli serotype 055:B5. The experimental design was a randomized complete block design in a 2 x 2 factorial arrangement with nine replicates per treatment and, one animal per experimental unit. The data were analyzed in accordance with the multivariate analysis procedure of SAS and, the treatment means of parametric and non-parametric data were compared by Bonferroni's test (P < 0.05) and, by Dunn's test (P < 0.05), respectively. The data of the blood profiles of alanine aminotransferase, alkaline phosphatase and, creatinine showed that LPS did not cause kidney or liver damage in the animals. The addition of beta-glucan in the diets did not prove the robustness of its effect and biological relevance when provided with low nutrient-density. However, its addition combined with the high-nutrient-density diets showed less marked hypoglobulinemia in piglets, which may have contributed to the decreasing of the synthesis of inflammatory mediators. (C) 2015 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 12/03146-3 - Immunomodulatory action of beta-glucans in weaned piglets fed with diets of different nutritional densities
Grantee:Dirlei Antonio Berto
Support type: Regular Research Grants