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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The sleep characteristics in symptomatic patients with Duchenne muscular dystrophy

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Author(s):
Nozoe, Karen Tieme [1] ; Moreira, Gustavo Antonio [1] ; Corradini Tolino, Jose Rodolfo [1] ; Pradella-Hallinan, Marcia [1] ; Tufik, Sergio [1] ; Andersen, Monica Levy [1]
Total Authors: 6
Affiliation:
[1] Univ Fed Sao Paulo, Dept Psychobiol, Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Sleep and Breathing; v. 19, n. 3, p. 1051-1056, SEP 2015.
Web of Science Citations: 8
Abstract

Duchenne muscular dystrophy (DMD) causes serious health consequences that include impairment of the respiratory system and sleep. The aim of our study is to investigate the sleep architecture and respiratory profile during sleep of symptomatic patients with DMD without ventilatory support. We evaluated polysomnography (PSG) of boys with DMD (n = 44) and a control group (n = 79) with sleep complaints that was matched in age but without neuromuscular disease. DMD patients presented sleep impairments when compared with the control group in terms of decreased sleep efficiency (72.4 +/- 1.9 vs 80.3 +/- 1.4 %, P = 0.002) and increased apnea-hypopnea index (AHI) during nonrapid eye movement (NREM) sleep (1.6 +/- 0.3 vs 0.3 +/- 0.2/h, P = 0.003). The main changes were observed during rapid eye movement (REM) sleep: an increase in REM sleep latency (202.2 +/- 11.8 vs 152.3 +/- 8.6 min, P < 0.001), a reduced percentage of REM sleep (13.1 +/- 0.9 vs 17.9 +/- 0.7 %, P = 0.001), and exacerbation of AHI (8.7 +/- 1.5 vs 1.0 +/- 1.1 events/h, P = 0.001). There was an increase in the total number of apneas, especially obstructive apneas (6.8 +/- 1.9 vs 0.8 +/- 1.3, P = 0.013). The sleep and respiratory profile during sleep of patients with DMD are compromised. The results suggest that these changes reflect the muscle weakness inherent in DMD and are demonstrated mainly during REM sleep. Thus, the use of PSG is important to identify sleep-disordered breathing at an early stage, before deciding when to introduce noninvasive respiratory support for prevention of respiratory complications. (AU)

FAPESP's process: 14/08067-0 - Profile of physical and psychological health of mothers-caregivers of children with Duchenne Muscular Dystrophy
Grantee:Karen Tieme Nozoe
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)