| Full text | |
| Author(s): |
Kim, Jayoung
[1]
;
Imani, Somayeh
[2]
;
de Araujo, William R.
[3, 1]
;
Warchall, Julian
[2]
;
Valdes-Ramirez, Gabriela
[1]
;
Paixao, Thiago R. L. C.
[3]
;
Mercier, Patrick P.
[2]
;
Wang, Joseph
[1]
Total Authors: 8
|
| Affiliation: | [1] Univ Calif San Diego, Dept Nanoengn, La Jolla, CA 92093 - USA
[2] Univ Calif San Diego, Dept Elect & Comp Engn, La Jolla, CA 92093 - USA
[3] Univ Sao Paulo, Inst Quim, BR-05508000 Sao Paulo, SP - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | BIOSENSORS & BIOELECTRONICS; v. 74, p. 1061-1068, DEC 15 2015. |
| Web of Science Citations: | 99 |
| Abstract | |
This article demonstrates an instrumented mouthguard capable of non-invasively monitoring salivary uric acid (SUA) levels. The enzyme (uricase)-modified screen printed electrode system has been integrated onto a mouthguard platform along with anatomically-miniaturized instrumentation electronics featuring a potentiostat, microcontroller, and a Bluetooth Low Energy (BLE) transceiver. Unlike REID-based biosensing systems, which require large proximal power sources, the developed platform enables real-time wireless transmission of the sensed information to standard smartphones, laptops, and other consumer electronics for on-demand processing, diagnostics, or storage. The mouthguard biosensor system offers high sensitivity, selectivity, and stability towards uric acid detection in human saliva, covering the concentration ranges for both healthy people and hyperuricemia patients. The new wireless mouthguard biosensor system is able to monitor SUA level in real-time and continuous fashion, and can be readily expanded to an array of sensors for different analytes to enable an attractive wearable monitoring system for diverse health and fitness applications. (C) 2015 Elsevier B.V. All rights reserved. (AU) | |
| FAPESP's process: | 14/00788-0 - Development of electrochemical sensors for detection and discrimination of forensic samples |
| Grantee: | William Reis de Araujo |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate (Direct) |