Cross-sensitization between testosterone and cocaine in adolescent and adult rats

Author(s)

Engi, Sheila A. ^{[1, 2]} ; Cruz, Fabio C. ^[2] ; Crestani, Carlos C. ^{[1, 2]} ; Planeta, Cleopatra S. ^{[1, 2]}

Affiliation

^[1] Joint Grad Program Physiol Sci UFSCar UNESP, BR-13565905 Sao Carlos, SP - Brazil

^[2] Univ Estadual Paulista UNESP, Pharmacol Lab, Sch Pharmaceut Sci, BR-14801902 Araraquara, SP - Brazil

• Document type: Journal article
• Source: INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE; v. 46, p. 33-37, NOV 2015.
• Web of Science Citations: 3

Abstract

Cocaine and anabolic-androgenic steroids are substances commonly co-abused. The use of anabolic steroids and cocaine has increased among adolescents. However, few studies investigated the consequences of the interaction between anabolic-androgenic steroids in animals' model of adolescence. We examined the effects of acute and repeated testosterone administration on cocaine-induced locomotor activity in adult and adolescent rats. Rats received ten once-daily subcutaneous (s.c.) injections of testosterone (10 mg/kg) or vehicle. Three days after the last testosterone or vehicle injections rats received an intraperitoneal (i.p.) challenge injection of either saline or cocaine (10 mg/kg). A different subset of rats was treated with a single injection of testosterone (10 mg/kg) or vehicle and three days later was challenged with cocaine (10 mg/kg, i.p.) or saline. Immediately after cocaine or saline injections the locomotor activity was recorded during forty minutes. Our results demonstrated that repeated testosterone induced locomotor sensitization to cocaine in adolescent but not adult rats. (C) 2015 Published by Elsevier Ltd. on behalf of ISDN. (AU)

• FAPESP's process: 10/04737-0 - Central and peripheral effects resulting from exposure to cocaine and testosterone in adolescent and adult rats
• Grantee: Sheila Antonagi Engi
• Support Opportunities: Scholarships in Brazil - Master