| Full text | |
| Author(s): |
Ullah, Farhad
[1]
;
dos Anjos-Garcia, Tayllon
[1]
;
dos Santos, Ieda Regina
[1]
;
Biagioni, Audrey Francisco
[1]
;
Coimbra, Norberto Cysne
[1, 2]
Total Authors: 5
|
| Affiliation: | [1] Univ Sao Paulo, Dept Pharmacol, Lab Neuroanat & Neuropsychobiol, Ribeirao Preto Med Sch, BR-14049900 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Fac Med Ribeirao Preto, NAP USP Neurobiol Emot NuPNE Res Ctr, BR-14049900 Ribeirao Preto, SP - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | Behavioural Brain Research; v. 293, p. 143-152, OCT 15 2015. |
| Web of Science Citations: | 26 |
| Abstract | |
Electrical stimulation of the periaqueductal gray matter and ventromedial hypothalamus in humans showed the involvement of both these structures in panic attacks. The aim of this work was to make clear the role of dorsal periaqueductal gray (dPAG) matter, dorsomedial hypothalamus (DMH) and the dorsomedial part of the ventromedial hypothalamus (dmVMH) in panic attack-like behaviors. DMH, dmVMH and dPAG of Wistar rats were treated with N-methyl-D-aspartic acid (NMDA) at different doses. The rodents were then kept in a polygonal arena with a burrow to record panic attack-like responses and oriented defensive behaviors. In dmVMH, 6 nmol of NMDA elicited alertness, freezing and oriented escape. The same set of behaviors was elicited by DMH neurons when stimulated by 9 nmol of NMDA. Treatment of dmVMH with 9 nmol of NMDA elicited typical explosive behaviors followed by freezing and oriented behaviors. The stimulation of the dPAG with NMDA at different doses provoked alertness and freezing (1 nmol) or alertness, freezing, tail twitching, explosive behavior and oriented escape (3 nmol), and explosive behavior followed by long-lasting freezing (6 nmol). These data suggest that mainly dPAG plays a role in panic attack-like behaviors that resemble panic syndrome in humans. However, hypothalamic nuclei like dmVMH that mainly elicits oriented escape, can also produce explosive reaction when stimulated with 9 nmol NMDA, whereas, DMH plays a role in coordinating defensive behaviors. (C) 2015 Elsevier B.V. All rights reserved. (AU) | |
| FAPESP's process: | 14/10742-7 - Paresthesia as a new approach of study for panic disorder: basic and clinical research |
| Grantee: | Audrey Franceschi Biagioni |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 08/08955-1 - Involvement of the Dorsal Raphe Nucleus Neural Networks and Serotonergic Neurotransmittion in the Locus Coeruleus in Antinociceptive Processess Induced by Oriented Escape Reaction Evoked by Chemical Stimulation of the Medial Hypothalamus. |
| Grantee: | Audrey Franceschi Biagioni |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 12/03798-0 - Involvement of opioid and endocanabinoid receptors of the substantia nigra on the activity of Nigro-Tectal GABAergic pathways during defensive behaviour elicited by rodents confronted with venomous snakes |
| Grantee: | Norberto Cysne Coimbra |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 07/01174-1 - Study of the Involvement of opioid-, serotonergic- and noradrenergic-mechanisms of the pain endogenous inhibitory system in antinociceptive processes induced by oriented escape reactions evoked by chemical stimulation of the merdial hypothalamus |
| Grantee: | Norberto Cysne Coimbra |
| Support Opportunities: | Regular Research Grants |