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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Amperometric Folic Acid Quantification Using a Supramolecular Tetraruthenated Nickel Porphyrin mu-Peroxo-Bridged Matrix Modified Electrode Associated to Batch Injection Analysis

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Author(s):
Ferreira, Luis M. C. [1] ; Martins, Paulo R. [2] ; Araki, Koiti [1] ; Toma, Henrique H. [1] ; Angnes, Lucio [1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Inst Quim, BR-05508000 Sao Paulo, SP - Brazil
[2] Univ Fed Goias, Inst Quim, BR-74001970 Goiania, Go - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Electroanalysis; v. 27, n. 10, p. 2322-2328, OCT 2015.
Web of Science Citations: 7
Abstract

A supramolecular Nickel (II) porphyrin complex containing four pyridyl-bis(2,2-bipyridyl)chloro ruthenium meso substituents was submitted to successive voltammetric cycles in high alkaline media to produce a supramolecular matrix with Nickel centers linked by mu-peroxo bridges, producing a highly stable thin film able to act as redox mediator for electrocatalytic oxidation of folic acid. The characterization of electrode surface material was performed by Scanning Electron Microscopy and Electrochemical Impedance Spectroscopy. The modified electrode was inserted into a batch injection electrochemical cell used for the rapid and precise quantification of folic acid in pharmaceutical products. The favorable hydrodynamic conditions provided by amperometry-BIA association allowed a very high throughput with good linear range (1 to 200 mu molL(-1)) and low detection limit (7.37x10(-7)molL(-1)). The electrochemical method was applied to the quantification of folic acid in different tablet samples. The results were comparable with values indicated by the manufacturer and those found using high HPLC according to the Brazilian Pharmacopoeia; commercial samples were submitted to a procedure in order to remove lactose of tablets, since carbohydrates act as interfering species. This procedure together with the electrochemical method showed to be simple, rapid, efficient and an appropriate alternative for quantifying this compound in real samples. (AU)

FAPESP's process: 11/21227-8 - Development of amperometric sensors based on mixed sol of a-NiCo(OH)2 and nickel/cobalt oxides and their association with carbon nanotubes/graphene
Grantee:Paulo Roberto Martins
Support Opportunities: Scholarships in Brazil - Post-Doctoral