Genistein reduces the noxious effects of in utero bisphenol A exposure on the rat prostate gland at weaning and in adulthood

Author(s)

Bernardo, Bruna Dias ^[1] ; Brandt, Joyce Zalotti ^[2] ; Grassi, Tony Fernando ^[1] ; Silveira, Livia Teresa R. ^[2] ; Scarano, Wellerson Rodrigo ^[2] ; Barbisan, Luis Fernando ^[2]

Affiliation

^[1] UNESP Univ Estadual Paulista, Sch Med, Dept Pathol, BR-18618970 Botucatu, SP - Brazil

^[2] UNESP Univ Estadual Paulista, Inst Biosci, Dept Morphol, BR-18618970 Botucatu, SP - Brazil

• Document type: Journal article
• Source: Food and Chemical Toxicology; v. 84, p. 64-73, OCT 2015.
• Web of Science Citations: 10

Abstract

Bisphenol A (BPA) is one hormonally active chemical with potential deleterious effects on reproductive organs, including breast and prostate. In contrast, genistein (GEN) is the major phytoestrogen of soy that presents potential protective effects against hormone-dependent cancers, including that of the prostate. Thus, pregnant Sprague Dawley rats were treated with BPA at 25 or 250 mu g/kg/day by gavage from gestational day (GD) 10-21 with or without dietary GEN at 250 mg/kg/chow (similar to 5.5 mg/kg/day). Then, male offspring from different litters were euthanized on post-natal day (PND) 21 and 180. At PND21, BPA 25 exposure induced early prostatic changes while dietary GEN attenuated some deleterious actions this xenoestrogen on epithelial cell proliferation levels, androgen receptor expression and prostatic architecture in male offspring. At PND180, a significant increase in incidence of prostatic multifocal inflammation/reactive hyperplasia and atypical hyperplasia were observed in male offspring from dams that received BPA 25. On the other hand, maternal GEN feeding attenuated some the adverse effects of BPA 25 on prostate disease at late-in-life. This way, the present findings point to preventive action of dietary GEN on deleterious effects of gestational BPA exposure in both early and late prostate development in offspring Fl. (C) 2015 Elsevier Ltd. All rights reserved. (AU)

• FAPESP's process: 10/17262-0 - In utero and lactational exposure to endocrine desrupter bisphenol A and to chemopreventive agent Indol-3-Carbinol: effects on early prostate morphogenesis and susceptibility to prostate carcinogenesis in male Sprague-Dawley rats
• Grantee: Joyce Zalotti Brandt
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 10/14110-4 - In Utero endocrine-disrupting bisphenol A exposure and chemopreventive agents on susceptibility to mammary carcinogenesis in female Sprague-Dawley.
• Grantee: Luís Fernando Barbisan
• Support Opportunities: Regular Research Grants