| Full text | |
| Author(s): |
Cruvinel, Wilson de Melo
[1]
;
Mesquita Junior, Danilo
[2]
;
Pereira Araujo, Julio Antonio
[2]
;
Samazi, Karina Carvalho
[3]
;
Kallas, Esper Georges
[3]
;
Cendoroglo, Maysa Seabra
[4]
;
Coelho Andrade, Luis Eduardo
[2]
Total Authors: 7
|
| Affiliation: | [1] Pontificia Univ Catolica Goias, Sch Med Pharmaceut & Biomed Sci, Goiania, Go - Brazil
[2] Univ Fed Sao Paulo, Div Rheumatol, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Div Clin Immunol & Allergy, Sao Paulo, SP - Brazil
[4] Univ Fed Sao Paulo, Div Geriatr, Sao Paulo, SP - Brazil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | Revista da Associação Médica Brasileira; v. 61, n. 4, p. 329-335, JUL-AUG 2015. |
| Web of Science Citations: | 0 |
| Abstract | |
SummaryIntroduction:aging is associated with several immunologic changes. Regulatory (Treg) and effector T cells are involved in the pathogenesis of infectious, neoplastic, and autoimmune diseases. Little is known about the effects of aging on the frequency and function of these T cell subpopulations.Methods:peripheral blood mononuclear cells (PBMC) were obtained from 26 young (under 44 years old) and 18 elderly (above 80 years old) healthy women. T cell subpopulations were analyzed by flow cytometry.Results:elderly individuals had lower frequency of several activated effector T cell phenotypes as compared with young individuals: CD3+CD4+CD25+ (3.82±1.93 versus 9.53±4.49; p<0.0001); CD3+CD4+CD25+CD127+(2.39±1.19 versus 7.26±3.84; p<0.0001); CD3+CD4+CD25+ (0.41±0.22 versus 1.86±0.85, p<0.0001); and CD3+CD4+CD25highCD127+(0.06±0.038 versus 0.94±0.64, p<0.0001). Treg (CD3+CD4+CD25+CD127øFoxp3+) presented lower frequency in elderly individuals as compared to young adults (0.34±0.18 versus 0.76±0.48; p=0.0004) and its frequency was inversely correlated with age in the whole group (r=-0.439; p=0.013). The elderly group showed higher frequency of two undefined CD25øFoxp3+ phenotypes: CD3+CD4+CD25øFoxp3+(15.05±7.34 versus 1.65±1.71; p<0.0001) and CD3+CD4+CD25øCD127øFoxp3+(13.0±5.52 versus 3.51±2.87; p<0.0001).Conclusions:the altered proportion of different T cell subsets herein documented in healthy elderly women may be relevant to the understanding of the immunologic behavior and disease susceptibility patterns observed in geriatric patients. (AU) | |