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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Corticotrophin-releasing factor receptor 2 mediates the enhanced activation of satiety-related responses through oxytocin neurons in the paraventricular nucleus of the hypothalamus after adrenalectomy

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Author(s):
Uchoa, Ernane Torres [1, 2] ; Rorato, Rodrigo [1] ; Ruginsk, Silvia Graciela [1, 3] ; Borges, Beatriz de Carvalho [1] ; Antunes-Rodrigues, Jose [1] ; Elias, Lucila L. K. [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Dept Physiol, Sch Med Ribeirao Preto, Sao Paulo - Brazil
[2] Univ Estadual Londrina, Dept Physiol Sci, BR-86051990 Londrina, PR - Brazil
[3] Univ Fed Alfenas, Inst Biomed Sci, Dept Physiol Sci, Alfenas - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Neuroscience Letters; v. 606, p. 123-128, OCT 8 2015.
Web of Science Citations: 1
Abstract

Adrenalectomy (ADX)-induced hypophagia is associated with increased activation of corticotrophin-releasing factor (CRF) and oxytocin (OT) neurons in the paraventricular nucleus of the hypothalamus (PVN) after refeeding. CRF2- and OT-receptor antagonists abolish the hypophagia and the augmented activation of the nucleus of the solitary tract neurons induced by feeding after ADX. In addition, OT-receptor antagonist reversed CRF-induced anorexia. We evaluated the effect of intracerebroventricular pretreatment with CRF2-receptor antagonist, antisauvagine-30 (AS30), on the activation of OT neurons of the PVN in response to refeeding of sham, adrenalectomized (ADX) and ADX rats replaced with corticosterone (ADX+B). In vehicle-pretreated animals, refeeding increased the number of Fos + OT double labeled neurons in the posterior parvocellular subdivision of the PVN (PaPo) of sham, ADX and ADX+B animals, with higher Fos expression and OT neuronal activation in the ADX group. AS30 reversed refeedinginduced increased activation of OT and non-OT neurons in the PaPo in the ADX group. In the medial parvocellular subdivision of the PVN (PaMP) of vehicle-pretreated animals, the number of Fos- and Fos + OT-immunoreactive neurons was increased after refeeding in ADX group. AS30 in the ADX group attenuated the enhanced Fos expression but not the number of Fos + OT double labeled neurons in the PaMP. In conclusion, CRF2-receptor antagonist reverses the increased activation of OT neurons in the PaPo induced by feeding in ADX animals, suggesting that OT neurons might be downstream mediators of CRF effects on satiety-related responses after ADX. (C) 2015 Elsevier Ireland Ltd. All rights reserved. (AU)

FAPESP's process: 13/09799-1 - Energy balance and body fluid homeostasis control: from cells to the physiological systems
Grantee:José Antunes Rodrigues
Support Opportunities: Research Projects - Thematic Grants