| Full text | |
| Author(s): |
Malheiros, Jackeline Moraes
[1, 2]
;
Paiva, Fernando Fernandes
[2]
;
Longo, Beatriz Monteiro
[1]
;
Hamani, Clement
[3, 1, 4]
;
Covolan, Luciene
[1]
Total Authors: 5
|
| Affiliation: | [1] Univ Fed Sao Paulo UNIFESP, Dept Physiol, Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Phys Sao Carlos, Ctr Imagens & Espect Ressonancia Magnet, Sao Carlos, SP - Brazil
[3] Ctr Addict & Mental Hlth, Res Imaging Ctr, Toronto, ON - Canada
[4] Campbell Family Mental Hlth Res Inst, Ctr Addict & Mental Hlth, Toronto, ON - Canada
Total Affiliations: 4
|
| Document type: | Review article |
| Source: | FRONTIERS IN NEUROLOGY; v. 6, JUL 10 2015. |
| Web of Science Citations: | 22 |
| Abstract | |
Magnetic resonance imaging (MRI) is an excellent non-invasive tool to investigate biological systems. The administration of the paramagnetic divalent ion manganese (Mn2+) enhances MRI contrast in vivo. Due to similarities between Mn2+ and calcium (Ca2+), the premise of manganese-enhanced MRI (MEMRI) is that the former may enter neurons and other excitable cells through voltage-gated Ca2+ channels. As such, MEMRI has been used to trace neuronal pathways, define morphological boundaries, and study connectivity in morphological and functional imaging studies. In this article, we provide a brief overview of MEMRI and discuss recently published data to illustrate the usefulness of this method, particularly in animal models. (AU) | |
| FAPESP's process: | 05/56663-1 - Magnetic resonance imaging and in vivo spectroscopy center for animal model studies |
| Grantee: | Alberto Tannús |
| Support Opportunities: | Inter-institutional Cooperation in Support of Brain Research (CINAPCE) - Thematic Grants |