| Full text | |
| Author(s): |
Dong, Xiaoxi
[1]
;
Yambartsev, Anatoly
[2]
;
Ramsey, Stephen A.
[3, 4]
;
Thomas, Lina D.
[2]
;
Shulzhenko, Natalia
[4]
;
Morgun, Andrey
[1]
Total Authors: 6
|
| Affiliation: | [1] Oregon State Univ, Coll Pharm, Corvallis, OR 97331 - USA
[2] Univ Sao Paulo, Inst Math & Stat, Dept Stat, Sao Paulo, SP - Brazil
[3] Oregon State Univ, Dept Biomed Sci, Sch Elect Engn & Comp Sci, Corvallis, OR 97331 - USA
[4] Oregon State Univ, Coll Vet Med, Dept Biomed Sci, Corvallis, OR 97331 - USA
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | BIOINFORMATICS AND BIOLOGY INSIGHTS; v. 9, p. 61-74, 2015. |
| Web of Science Citations: | 12 |
| Abstract | |
Ornics technologies enable unbiased ins investigation of biological systems through massively parallel sequence acquisition or molecular measurements, bringing the life sciences into the era of Big Data. A central challenge posed by such omics datasets is how to transform these data into biological knowledge, for example, how to use these data to answer questions such as: Which functional pathways are involved in cell differentiation? Which genes should we target to stop cancer? Network analysis is a powerful and general approach to solve this problem consisting of two fundamental stages. network reconstruction, and network interrogation. Here we provide an overview of network analysis including a step-by-step guide on how to perform and use this approach to investigate a biological question. In this guide, we also include the software packages that we and others employ for each of the steps of a network analysis workflow. (AU) | |
| FAPESP's process: | 13/06223-1 - New statistical inferences exploring causal changes in biological networks |
| Grantee: | Lina Dornelas Thomas |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 13/14722-8 - Study of changes in gene co-expression networks |
| Grantee: | Lina Dornelas Thomas |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate |