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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Aging does not affect the ability of human monocyte-derived dendritic cells to phagocytose Candida albicans

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Author(s):
Pereira do Nascimento, Magda Paula [1] ; Pinke, Karen Henriette [1] ; Penitenti, Marcimara [2] ; Valerio Ikoma, Maura Rosane [2] ; Lara, Vanessa Soares [1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Dept Stomatol, Bauru Sch Dent, BR-17012901 Bauru, SP - Brazil
[2] Amaral Carvalho Fdn, Flow Cytometry Lab, BR-17210080 Jau, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: AGING CLINICAL AND EXPERIMENTAL RESEARCH; v. 27, n. 6, p. 785-789, DEC 2015.
Web of Science Citations: 6
Abstract

Background Dendritic cells (DCs) are the most potent antigen-presenting cells, playing a key role in induction of both innate and adaptive immunity. Immunosenescence refers to age-associated changes in the immune system, which may be associated with susceptibility to infections and their clinical complications. The precise effects of aging on DCs in immunity to infections are not well understood. Among the common pathogenic microorganisms, the fungus Candida albicans is an important pathogen for the development of invasive infections, especially in immunocompromised individuals, as well as during aging. Aims To make a comparative in vitro evaluation of the immunomodulatory function of DCs challenged with C. albicans, by phagocytosis of the fungal cells, and determine the involvement of TLR2 and TLR4 receptors. For this purpose, DCs were generated with the use of peripheral blood monocytes from healthy young and aged subjects. Results The phagocytosis of C. albicans is developed by DCs in TLR2- and TLR4-dependent way. This mechanism is not affected by aging. Conclusion Given the important role of the DCs in responses against the fungus, it is evident that if changes in phagocytosis occurred with aging, impairment in the elderly could develop. However, the evidence that phagocytosis of this fungus by DCs is not impaired with aging, brings us to the question of which are the mechanisms truly associated with the prevalence of certain diseases in the elderly. (AU)

FAPESP's process: 10/15271-1 - Immunosenescence and dendritic cells: role of TLR2 and TLR4 in phagocytosis and cytokines production against Candida albicans
Grantee:Vanessa Soares Lara
Support type: Regular Research Grants
FAPESP's process: 09/17889-5 - Immunosenescence and dendritic cells: role of TLR2 and TLR4 in phagocytosis and cytokines production against Candida albicans .
Grantee:Magda Paula Pereira Do Nascimento
Support type: Scholarships in Brazil - Post-Doctorate