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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Pharmacological significance of the interplay between angiotensin receptors: MAS receptors as putative final mediators of the effects elicited by angiotensin ATi receptors antagonists

Full text
Author(s):
Pernomian, Larissa [1] ; Pernomian, Laena [1] ; Gomes, Mayara S. [1] ; da Silva, Carlos H. T. P. [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto FCFRP, BR-14049 Ribeirao Preto, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: European Journal of Pharmacology; v. 769, p. 143-146, DEC 15 2015.
Web of Science Citations: 3
Abstract

The interplay between angiotensin AT(1) receptors and MAS receptors relies on several inward regulatory mechanisms from renin-angiotensin system (RAS) including the functional crosstalk between angiotensin ll and angiotensin-(1-7), the competitive AT(1) antagonism exhibited by angiotensin-(1-7), the antagonist feature assigned to ATi/MAS heterodimerization on ATi signaling and the AT(1)-mediated downregulation of angiotensin-converting enzyme 2 (ACE2). Recently, such interplay has acquired an important significance to RAS Pharmacology since a few studies have supporting strong evidences that MAS receptors mediate the effects elicited by AT(1) antagonists. The present Perspective provides an overview of the regulatory mechanisms involving AT(1) and MAS receptors, their significance to RAS Pharmacology and the future directions on the interplay between angiotensin receptors. (C) 2015 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 14/17740-0 - Planning, development and pharmacological evaluation of new aryl hydrocarbon receptors (AhR) antagonists that are candidates for atheroprotective drugs
Grantee:Larissa Pernomian
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 13/08216-2 - CRID - Center for Research in Inflammatory Diseases
Grantee:Fernando de Queiroz Cunha
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 12/00640-7 - Study of the consequences of the inflammatory process induced by AT1 receptors during atherosclerosis on the ACE2 - angiotensin-(1-7) - Mas axis in mouse aorta and the involvement of Mas receptors in the vaso- and atheroprotective effects of losartan
Grantee:Larissa Pernomian
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 11/11205-7 - Modulation played by C-type natriuretic peptide (CNP) on the contractile response induced by phenylephrine on thoracic aorta and mesenteric resistance arteries isolated from rats submitted to septic shock
Grantee:Laena Pernomian
Support Opportunities: Scholarships in Brazil - Doctorate