Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Room-Temperature Organocatalytic Cycloaddition of Azides with beta-Keto Sulfones: Toward Sulfonyl-1,2,3-triazoles

Full text
Author(s):
Saraiva, Maiara T. [1] ; Costa, Gabriel P. [1] ; Seus, Natalia [1] ; Schumacher, Ricardo F. [1] ; Perin, Gelson [1] ; Paixao, Marcio W. [2] ; Luque, Rafael [3] ; Alves, Diego [1]
Total Authors: 8
Affiliation:
[1] Univ Fed Pelotas UPPel, LASOL CCQFA, BR-96010900 Pelotas, RS - Brazil
[2] Univ Fed Sao Carlos, Lab Sintese Prod Nat, BR-17012901 Sao Carlos, SP - Brazil
[3] Univ Cordoba, Dept Quim Organ, Cordoba 5016 - Spain
Total Affiliations: 3
Document type: Journal article
Source: ORGANIC LETTERS; v. 17, n. 24, p. 6206-6209, DEC 18 2015.
Web of Science Citations: 32
Abstract

Organocatalytic enamine-azide {[}3 + 2] cycloadditions between beta-keto sulfones and aryl azides can be performed at room temperature in good to excellent yields of products in the presence of catalytic amounts of pyrrolidine (5 mol %). The proposed organocatalytic methodology was found to be applicable to beta-keto arylsulfones containing a range of substituents. A wide variety of aryl azides also work. Basically, this constitutes a remarkably efficient protocol for the synthesis of novel 1,2,3-triazole compounds. (AU)

FAPESP's process: 15/17141-1 - Development and Mechanism Studies of New Synthetic Methodologies for the Synthesis of Bioactive Compounds.
Grantee:Ricardo Samuel Schwab
Support Opportunities: Regular Research Grants
FAPESP's process: 14/50249-8 - Green chemistry: sustainable synthetic methods employing benign solvents, safer reagents, and bio-renewable feedstock
Grantee:Arlene Gonçalves Corrêa
Support Opportunities: Research Grants - Research Centers in Engineering Program