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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Leishmania infection and neuroinflammation: Specific chemokine profile and absence of parasites in the brain of naturally-infected dogs

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Melo, Guilherme D. [1] ; Silva, Jose Eduardo S. [1] ; Grano, Femanda G. [1] ; Souza, Milena S. [2] ; Machado, Gisele F. [1]
Total Authors: 5
[1] UNESP Univ Estadual Paulista, Fac Med Vet, Lab Patol Aplicada LApap, Sao Paulo - Brazil
[2] UNESP Univ Estadual Paulista, Fac Med Vet, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Journal of Neuroimmunology; v. 289, p. 21-29, DEC 15 2015.
Web of Science Citations: 6

Visceral leishmaniasis is a chronic disease caused by Leishmania infantum. We aimed to detect the parasite in the brain of fifteen naturally-infected dogs using in situ hybridization and immunohistochemistry, and the gene expression of selected chemokines by RT-qPCR. We detected no parasite in the brain, but perivascular deposition of parasite DNA and IgG in the choroid plexus. We noticed up-regulation of CCL-3, CCL-4 and CCL-5, coherent with T lymphocyte accumulation, stating the brain as a pro-inflammatory environment. Indeed, not necessarily the parasite itself, but rather its DNA seems to act as a trigger to promote brain inflammation during visceral leishmaniasis. (C) 2015 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 12/10415-0 - Neuropathogenesis of canine visceral leishmaniasis: investigation of inflammatory mediators
Grantee:Guilherme Dias de Melo
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 12/23950-1 - Neuropathology of canine visceral leishmaniosis: investigation of inflammatory mediators
Grantee:Gisele Fabrino Machado
Support type: Regular Research Grants