| Full text | |
| Author(s): |
Melo, Guilherme D.
[1]
;
Silva, Jose Eduardo S.
[1]
;
Grano, Femanda G.
[1]
;
Souza, Milena S.
[2]
;
Machado, Gisele F.
[1]
Total Authors: 5
|
| Affiliation: | [1] UNESP Univ Estadual Paulista, Fac Med Vet, Lab Patol Aplicada LApap, Sao Paulo - Brazil
[2] UNESP Univ Estadual Paulista, Fac Med Vet, Sao Paulo - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | Journal of Neuroimmunology; v. 289, p. 21-29, DEC 15 2015. |
| Web of Science Citations: | 6 |
| Abstract | |
Visceral leishmaniasis is a chronic disease caused by Leishmania infantum. We aimed to detect the parasite in the brain of fifteen naturally-infected dogs using in situ hybridization and immunohistochemistry, and the gene expression of selected chemokines by RT-qPCR. We detected no parasite in the brain, but perivascular deposition of parasite DNA and IgG in the choroid plexus. We noticed up-regulation of CCL-3, CCL-4 and CCL-5, coherent with T lymphocyte accumulation, stating the brain as a pro-inflammatory environment. Indeed, not necessarily the parasite itself, but rather its DNA seems to act as a trigger to promote brain inflammation during visceral leishmaniasis. (C) 2015 Elsevier B.V. All rights reserved. (AU) | |
| FAPESP's process: | 12/23950-1 - Neuropathology of canine visceral leishmaniosis: investigation of inflammatory mediators |
| Grantee: | Gisele Fabrino Machado |
| Support type: | Regular Research Grants |
| FAPESP's process: | 12/10415-0 - Neuropathogenesis of canine visceral leishmaniasis: investigation of inflammatory mediators |
| Grantee: | Guilherme Dias de Melo |
| Support type: | Scholarships in Brazil - Doctorate |