Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Shared Genetic Factors of Anxiety and Depression Symptoms in a Brazilian Family-Based Cohort, the Baependi Heart Study

Full text
Author(s):
Taporoski, Tamara P. [1, 2] ; Negrao, Andre B. [1, 2] ; Horimoto, Andrea R. V. R. [2] ; Duarte, Nubia E. [2] ; Alvim, Rafael O. [3, 2] ; de Oliveira, Camila M. [3, 2] ; Krieger, Jose E. [2] ; von Schantz, Malcolm [2, 4] ; Vallada, Homero [1] ; Pereira, Alexandre C. [2]
Total Authors: 10
Affiliation:
[1] Univ Sao Paulo, Sch Med, Dept & Inst Psychiat LIM 23, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Sch Med, Inst Heart, Lab Genet & Mol Cardiol, Sao Paulo, SP - Brazil
[3] Univ Fed Juiz de Fora, Dept Physiol, Juiz De Fora, MG - Brazil
[4] Univ Surrey, Fac Hlth & Med Sci, Dept Biochem & Physiol, Guildford GU2 5XH, Surrey - England
Total Affiliations: 4
Document type: Journal article
Source: PLoS One; v. 10, n. 12 DEC 9 2015.
Web of Science Citations: 6
Abstract

To investigate the phenotypic and genetic overlap between anxiety and depression symptoms in an admixed population from extended family pedigrees. Participants (n = 1,375) were recruited from a cohort of 93 families (mean age +/- SD 42 +/- 16.3, 57% female) in the rural town of Baependi, Brazil. The Hospital Anxiety and Depression Scale (HADS) was used to assess depression and anxiety symptoms. Heritability estimates were obtained by an adjusted variance component model. Bivariate analyses were performed to obtain the partition of the covariance of anxiety and depression into genetic and environmental components, and to calculate the genetic contribution modulating both sets of symptoms. Anxiety and depression scores were 7.49 +/- 4.01 and 5.70 +/- 3.82, respectively. Mean scores were affected by age and were significantly higher in women. Heritability for depression and anxiety, corrected for age and sex, were 0.30 and 0.32, respectively. Significant genetic correlations (p(g) = 0.81) were found between anxiety and depression scores; thus, nearly 66% of the total genetic variance in one set of symptoms was shared with the other set. Our results provided strong evidence for a genetic overlap between anxiety and depression symptoms, which has relevance for our understanding of the biological basis of these constructs and could be exploited in genome-wide association studies. (AU)

FAPESP's process: 13/17368-0 - Cardiovascular genomics: mechanisms & novel therapeutics - CVGen mech2ther
Grantee:José Eduardo Krieger
Support Opportunities: Research Projects - Thematic Grants