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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Immunodetection of myeloid and plasmacytoid dendritic cells in mammary carcinomas of female dogs

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Author(s):
Rosolem, Mayara C. [1] ; Vasconcelos, Rosemeri O. [1] ; Garrido, Eduardo [2] ; Castanheira, Thais L. L. [3] ; Moreira, Pamela R. R. [1] ; Magalhaes, Georgia M. [4] ; Rozza, Daniela B. [5] ; Ramos, Salvador B. [6]
Total Authors: 8
Affiliation:
[1] Univ Estadual Paulista, Dept Patol Vet, FCAV, BR-14884900 Jaboticabal, SP - Brazil
[2] IFNMG, BR-39360000 Salinas, MG - Brazil
[3] Fac Integrado Campo Mourao, BR-87300970 Campo Mourao, PR - Brazil
[4] Univ Franca Unifran, Hosp Vet, BR-14404600 Franca, SP - Brazil
[5] UNESP, Dept Clin Cirurgia & Reprod Anim, Fac Med Vet FMVA, BR-16050680 Aracatuba, SP - Brazil
[6] FCAV Unesp, Dept Ciencias Exatas, BR-14884900 Jaboticabal, SP - Brazil
Total Affiliations: 6
Document type: Journal article
Source: Pesquisa Veterinária Brasileira; v. 35, n. 11, p. 906-912, NOV 2015.
Web of Science Citations: 0
Abstract

ABSTRACT: Dendritic cells have attracted great interest from researchers as they may be used as targets of tumor immune evasion mechanisms. The main objective of this study was to evaluate the relationship between the dendritic cells (DCs) subpopulation in simple type mammary carcinomas in female dogs. Two groups of samples were used: the control group consisted of 18 samples of mammary tissue without changes and the tumor group with 26 simple type mammary carcinomas. In these groups, we evaluated the immunodetection of immature and mature myeloid DCs, plasmacytoid DCs and MHC-II. In mammary tumor, mature myeloid DCs predominated in the peritumoral region, while immature myeloid DCs and plasmacytoid DCs were evident in the intratumoral region. Immunostaining of MHC-II was visualized in mammary acini (control group), in tumor cells and inflammatory infiltration associated with tumors. The comparison between the control and tumor groups showed a statistically significant difference between immature myeloid DCs, mature myeloid DCs and plasmacytoid DCs. The immunodetection of MHC-II was not significant when comparing the groups. The predominance of immature DCs in the tumor group is possibly related to an inefficient immune response, promoting the development and survival of tumor cells. The presence of plasmacytoid DCs in the same group suggests a worse prognosis for female dogs with mammary tumors. Therefore, the ability of differentiation of canine dendritic cells could be influenced by neoplastic cells and by the tumor microenvironment. (AU)

FAPESP's process: 11/03510-4 - The role of dendritic cells in the immune response of mammary tumors in dogs
Grantee:Mayara Caroline Rosolem
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 12/09385-0 - The influence of the immune response on the mammary carcinomas in female dogs
Grantee:Rosemeri de Oliveira Vasconcelos
Support Opportunities: Regular Research Grants