| Full text | |
| Author(s): |
de Moraes, Josue
[1]
;
Dario, Bruno S.
[2]
;
Couto, Ricardo A. A.
[2]
;
Pinto, Pedro L. S.
[3]
;
da Costa Ferreira, Ana M.
[2]
Total Authors: 5
|
| Affiliation: | [1] Univ Guarulhos, Nucleo Pesquisa Doencas Negligenciadas, Guarulhos, SP - Brazil
[2] Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, Sao Paulo, SP - Brazil
[3] Adolfo Lutz Inst, Nucleo Enteroparasitas, Sao Paulo, SP - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | Antimicrobial Agents and Chemotherapy; v. 59, n. 10, p. 6648-6652, OCT 2015. |
| Web of Science Citations: | 10 |
| Abstract | |
In recent years, a class of oxindole-copper and -zinc complex derivatives have been reported as compounds with efficient proapoptotic activity toward different tumor cells (e.g., neuroblastomas, melanomas, monocytes). Here we assessed the efficacy of synthesized oxindole-copper(II), -zinc(II), and -vanadyl (VO2+) complexes against adult Schistosoma mansoni worms. The copper( II) complexes (50% inhibitory concentrations of 30 to 45 mu M) demonstrated greater antischistosomal properties than the analogous zinc and vanadyl complexes regarding lethality, reduction of motor activity, and oviposition. (AU) | |
| FAPESP's process: | 11/50318-1 - Development of compounds with pharmacological or medicinal interest and of systems for their transport, detection and recognition in biological media |
| Grantee: | Ana Maria da Costa Ferreira |
| Support Opportunities: | Research Projects - Thematic Grants |