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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A genomewide association mapping study using ultrasound-scanned information identifies potential genomic regions and candidate genes affecting carcass traits in Nellore cattle

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Santana, M. H. A. [1] ; Ventura, R. V. [2, 1, 3] ; Utsunomiya, Y. T. [4] ; Neves, H. H. R. [5, 4] ; Alexandre, P. A. [1] ; Oliveira Junior, G. A. [1] ; Gomes, R. C. [6] ; Bonin, M. N. [6] ; Coutinho, L. L. [7] ; Garcia, J. F. [4] ; Silva, S. L. [1] ; Fukumasu, H. [1] ; Leme, P. R. [1] ; Ferraz, J. B. S. [1]
Total Authors: 14
[1] Univ Sao Paulo, Fac Zootecnia Engn Alimentos, BR-13635900 Pirassununga, SP - Brazil
[2] Univ Guelph, Ctr Genet Improvement Livestock, Guelph, ON N1G 2W1 - Canada
[3] BIO, Guelph, ON - Canada
[4] UNESP, Fac Ciencias Agr & Vet, Jaboticabal - Brazil
[5] GenSys Consultores Associados SC Ltda, Porto Alegre, RS - Brazil
[6] CNPGC EMBRAPA, Empresa Brasileira Pesquisa Agropecuaria, Campo Grande - Brazil
[7] Univ Sao Paulo, Escola Super Agr Luiz Queiroz, Piracicaba - Brazil
Total Affiliations: 7
Document type: Journal article
Source: JOURNAL OF ANIMAL BREEDING AND GENETICS; v. 132, n. 6, p. 420-427, DEC 2015.
Web of Science Citations: 9

The aim of this study was to identify candidate genes and genomic regions associated with ultrasound-derived measurements of the rib-eye area (REA), backfat thickness (BFT) and rumpfat thickness (RFT) in Nellore cattle. Data from 640 Nellore steers and young bulls with genotypes for 290 863 single nucleotide polymorphisms (SNPs) were used for genomewide association mapping. Significant SNP associations were explored to find possible candidate genes related to physiological processes. Several of the significant markers detected were mapped onto functional candidate genes including ARFGAP3, CLSTN2 and DPYD for REA; OSBPL3 and SUDS3 for BFT; and RARRES1 and VEPH1 for RFT. The physiological pathway related to lipid metabolism (CLSTN2, OSBPL3, RARRES1 and VEPH1) was identified. The significant markers within previously reported QTLs reinforce the importance of the genomic regions, and the other loci offer candidate genes that have not been related to carcass traits in previous investigations. (AU)

FAPESP's process: 14/14121-7 - System genetics studies of feedlot traits using super-dense SNP panel
Grantee:Miguel Henrique de Almeida Santana
Support type: Scholarships abroad - Research Internship - Post-doctor
FAPESP's process: 13/20571-2 - Functional genomics of feed intake and efficiency in Nellore cattle
Grantee:Miguel Henrique de Almeida Santana
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 12/02039-9 - Genomic study of feed intake and efficiency in Nellore cattle
Grantee:José Bento Sterman Ferraz
Support type: Regular Research Grants