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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Sleep-related movement disorder symptoms in SHR are attenuated by physical exercise and an angiotensin-converting enzyme inhibitor

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Author(s):
Frank, Miriam Kannebley [1] ; de Mello, Marco Tulio [2] ; Lee, Kil Sun [3] ; Daubian-Nose, Paulo [1] ; Tufik, Sergio [4] ; Esteves, Andrea Maculano [1]
Total Authors: 6
Affiliation:
[1] Univ Estadual Campinas, Fac Ciencias Aplicadas, Limeira - Brazil
[2] Univ Fed Minas Gerais, Dept Esportes, Belo Horizonte, MG - Brazil
[3] Univ Fed Sao Paulo, Dept Bioquim, Sao Paulo - Brazil
[4] Univ Fed Sao Paulo, Dept Psicobiol, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Physiology & Behavior; v. 154, p. 161-168, FEB 1 2016.
Web of Science Citations: 1
Abstract

The relationship between hypertension and sleep-related movement disorders has been hypothesized for humans, but the causes and mechanisms have not been elucidated. We investigated whether an alteration in blood pressure (BP) induced by physical exercise and/or an angiotensin-converting enzyme inhibitor (enalapril) could affect locomotor activity in spontaneously hypertensive rats, with emphasis on the dopaminergic system. We used SHR and normotensive Wistar rats distributed into 4 groups for each strain: control, physical exercise, enalapril and physical exercise + enalapril. Physical exercise was performed on a treadmill, and enalapril was administered by gavage, both for 8 weeks. During this period, locomotor activity was evaluated in an open field test, and BP was evaluated by tail plethysmography. Dopaminergic receptors, dopamine transporter and tyrosine hydroxylase levels at the striatum were evaluated by Western blotting. The control group of spontaneously hypertensive rats showed higher BP, increased activity in the open field test and lower levels of D2 receptors and tyrosine hydroxylase compared with all other groups throughout the experimental period. In general, physical exercise and enalapril attenuated these alterations. This study suggested the existence of comorbidity between hypertension and sleep-related movement disorders in spontaneously hypertensive rats. Physical exercise and enalapril conferred protection for both hypertension and the observed behavioral changes. In addition, these treatments led to changes in dopaminergic signaling in the striatal region (i.e., D2 receptor, TH and DAT). (C) 2015 Elsevier Inc All rights reserved. (AU)

FAPESP's process: 11/21729-3 - Evaluation of the influence of physical exercise on locomotor activity and blood pressure in an animal model of hypertension
Grantee:Andrea Maculano Esteves
Support type: Regular Research Grants
FAPESP's process: 13/22413-5 - Alterations of biochemical properties and functions of PrPc induced by endogenous dopamine metabolites and oligomeric amyloid beta peptide
Grantee:Kil Sun Lee
Support type: Regular Research Grants