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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Innate Sensing of the Gut Microbiota: Modulation of Inflammatory and Autoimmune Diseases

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Author(s):
Ignacio, Aline [1] ; Morales, Camila Ideli [1] ; Saraiva Camara, Niels Olsen [2, 1, 3] ; Almeida, Rafael Ribeiro [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Lab Transplantat Immunobiol, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Med, Div Nephrol, Sao Paulo - Brazil
[3] Univ Sao Paulo, Renal Pathophysiol Lab, Dept Clin Med, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Review article
Source: FRONTIERS IN IMMUNOLOGY; v. 7, FEB 19 2016.
Web of Science Citations: 31
Abstract

The mammalian gastrointestinal tract harbors a diverse microbial community with which dynamic interactions have been established over millennia of coevolution. Commensal bacteria and their products are sensed by innate receptors expressed in gut epithelia and in gut-associated immune cells, thereby promoting the proper development of mucosal immune system and host homeostasis. Many studies have demonstrated that host-microbiota interactions play a key role during local and systemic immunity. Therefore, this review will focus on how innate sensing of the gut microbiota and their metabolites through inflammasome and toll-like receptors impact the modulation of a distinct set of inflammatory and autoimmune diseases. We believe that a better understanding of the fine-tuning that governs host-microbiota interactions will further improve common prophylactic and therapeutic applications. (AU)

FAPESP's process: 12/02270-2 - New cellular, molecular and immunological mechanisms involved in acute and chronic renal injury: the search for new therapeutical approaches
Grantee:Niels Olsen Saraiva Câmara
Support Opportunities: Research Projects - Thematic Grants