| Full text | |
| Author(s): |
Pignaton, Wangles
[1]
;
Loureiro Luna, Stelio Pacca
[1, 2]
;
Teixeira Neto, Francisco Jose
[1, 2]
;
de Oliveira, Flavia Augusta
[1]
;
de Castro Neto, Eduardo Ferreira
[3]
;
Naffah-Mazzacoratti, Maria da Graca
[3]
;
Gozalo-Marcilla, Miguel
[2]
Total Authors: 7
|
| Affiliation: | [1] UNESP Univ Estadual Paulista, Sch Med, Dept Anesthesiol, Sao Paulo - Brazil
[2] UNESP Univ Estadual Paulista, Sch Vet Med & Anim Sci, Dept Vet Surg & Anesthesiol, Dist Rubiao Jr S-N, BR-18618970 Sao Paulo - Brazil
[3] Univ Fed Sao Paulo, Dept Biochem, Escola Paulista Med, Sao Paulo - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | Journal of Equine Veterinary Science; v. 37, p. 39-45, FEB 2016. |
| Web of Science Citations: | 0 |
| Abstract | |
Catecholamines and arginine vasopressin (AVP) release can affect arterial blood pressure (ABP) and hemodynamic stability in standing, sedated horses. Six mature horses were included in this prospective, randomized, crossover, blinded, experimental study. All the horses were sedated with detomidine (DET) alone (0.01 mg/kg, IV) or combined with methadone (MET) (0.01 mg/kg DET and 0.2 mg/kg MET, IV). Cardiopulmonary data and blood samples were collected 30 minutes before (prebaseline and baseline) and for 120 minutes postinjection. The combination DET/MET produced a significant increase (31%) in mean ABP (MAP) 5 minutes after drug administration which lasted for 120 minutes. Detomidine alone induced only a short-term increase in MAP (15%) at 5 minutes compared with baseline. There were significant differences between groups at 5, 15, and from 60 to 120 minutes. Plasma AVP concentrations were higher in horses receiving the treatment DET from 60 to 120 minutes than those in the combination group, for the same period. There were no significant differences in norepinephrine and epinephrine serum concentrations respect to baseline and between treatments. Detomidine induces a short-term MAP increase, and this effect was prolonged and potentiated by MET association. There is no evidence of AVP, norepinephrine, and epinephrine involvement in this effect. (C) 2016 Elsevier Inc. All rights reserved. (AU) | |