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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

beta-Cell Function Improvements in Grade I/II Obese Subjects With Type 2 Diabetes 1 Month After Biliopancreatic Diversion Results from modeling analyses of oral glucose tolerance tests and hyperglycemic clamp studies

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Author(s):
Junqueira Vasques, Ana Carolina [1] ; Pareja, Jose Carlos [1, 2] ; de Oliveira, Maria da Saude [1] ; Novaes, Fernanda Satake [1] ; de Oliveira Lima, Marcelo Miranda [1] ; Chaim, Elinton A. [2] ; Piccinini, Francesca [3] ; Dalla Man, Chiara [3] ; Cobelli, Claudio [3] ; Geloneze, Bruno [1]
Total Authors: 10
Affiliation:
[1] Univ Estadual Campinas, Gastroctr, Lab Invest Metab & Diabet, Sao Paulo - Brazil
[2] Univ Estadual Campinas, Dept Surg, Diabet Surg Unit, Sao Paulo - Brazil
[3] Univ Padua, Dept Informat Engn, Padua - Italy
Total Affiliations: 3
Document type: Journal article
Source: DIABETES CARE; v. 36, n. 12, p. 4117-4124, DEC 2013.
Web of Science Citations: 6
Abstract

OBJECTIVETo investigate the effect of biliopancreatic diversion (BPD) surgery on -cell function in grade I and II obese patients with type 2 diabetes using oral and intravenous glucose loads.RESEARCH DESIGN AND METHODSSixty-eight women were divided into the following three groups: 19 lean-control (23.0 2.2 kg/m(2)) and 18 obese-control (35.0 4.8 kg/m(2)) subjects with normal glucose tolerance, and 31 obese patients with type 2 diabetes (36.3 +/- 3.7 kg/m(2)). Of the 31 diabetic women, 64% underwent BPD (n = 20, BMI: 36.5 +/- 3.7 kg/m(2)) and were reassessed 1 month after surgery. Oral glucose tolerance tests and hyperglycemic clamps were performed. Mathematical modeling was used to analyze basal and stimulated -cell function, insulin sensitivity (IS), hepatic extraction (HE) of insulin, and delay time of -cell response to a specific plasma glucose concentration.RESULTSAfter BPD, restoration of the basal disposition index (P < 0.001) and improvement of the stimulated disposition indices in oral and intravenous glucose stimulation of the -cell were observed (P < 0.05). In both dynamic tests, there were no changes in the delay time of -cell response. IS for oral glucose stimulation (ISoral) and intravenous clamp glucose stimulation (ISclamp) was completely normalized (P < 0.001). ISoral and ISclamp increased approximately 5.0-fold and 3.5-fold, respectively (P < 0.01). The HE of insulin increased in the basal (P < 0.05) and stimulated states (P < 0.01).CONCLUSIONS-Cell function, IS, and HE of insulin improved after BPD, which improved glycemic control. (AU)

FAPESP's process: 08/09451-7 - Insulin secretory capacity in healthy patients, in obese, in obese type 2 diabetes and in obese type 2 diabetes undergoing bariatric surgery through the hyperglycemic clamp.
Grantee:Bruno Geloneze Neto
Support Opportunities: Regular Research Grants
FAPESP's process: 08/07312-0 - Insulin secretory capacity in healthy patients, in obese, in obese type 2 diabetes and in obese type 2 diabetes undergoing bariatric surgery through the hyperglycemic clamp
Grantee:Ana Carolina Junqueira Vasques
Support Opportunities: Scholarships in Brazil - Doctorate