Cognition in at-risk mental states for psychosis

Author(s)

Damiao de Paula, Andre Luiz ^{[1, 2]} ; Cecilio Hallak, Jaime Eduardo ^{[1, 2]} ; Maia-de-Oliveira, Joao Paulo ^{[3, 2]} ; Bressan, Rodrigo A. ^[4] ; Machado-de-Sousa, Joao Paulo ^{[1, 2]}

Affiliation

^[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Neurosci & Behav, BR-14048900 Ribeirao Preto, SP - Brazil

^[2] CNPq, Natl Inst Translat Med, Sao Paulo - Brazil

^[3] Univ Fed Rio Grande do Norte, Dept Clin Med, BR-59072970 Natal, RN - Brazil

^[4] Univ Fed Sao Paulo, Sao Paulo - Brazil

• Document type: Review article
• Source: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS; v. 57, p. 199-208, OCT 2015.
• Web of Science Citations: 18

Abstract

Rationale: The devastating nature of schizophrenia and treatment limitations have triggered a search for early detection methods to enable interventions to be implemented as soon as the first signs and symptoms appear. In this effort, several studies have investigated the cognitive functions in individuals regarded as being in at-risk mental states (ARMS) for psychosis. Objective: Our aim was to make a systematic review of the literature regarding basic and social cognition in individuals in ARMS following the guidelines of the PRISMA statement. Results: In general, the results of the 49 articles included in the review show that individuals in ARMS have pervasive cognitive deficits that seem to be greater in individuals who later convert to psychosis. Conclusions: Cognitive impairment can be detected in individuals considered to be in ARMS according to current classifications and may serve as a risk marker for psychotic conversion; however, the lack of standardized criteria to define ARMS and of homogeneous cognitive assessment methods hamper the generalization of findings from different studies. (C) 2015 Elsevier Ltd. All rights reserved. (AU)

• FAPESP's process: 11/50740-5 - Prevention in schizophrenia and bipolar disorder from neuroscience to the community: a multiphase, multimodal and translational platform for research and intervention
• Grantee: Rodrigo Affonseca Bressan
• Support Opportunities: Research Projects - Thematic Grants