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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

MRI Texture Analysis Reveals Bulbar Abnormalities in Friedreich Ataxia

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Author(s):
Santos, T. A. [1, 2] ; Maistro, C. E. B. [1, 2] ; Silva, C. B. [3, 2] ; Oliveira, M. S. [1, 2] ; Franca, Jr., M. C. [2, 3] ; Castellano, G. [1, 2]
Total Authors: 6
Affiliation:
[1] Univ Estadual Campinas, Sch Med Sci, Gleb Wataghin Phys Inst, Neurophys Grp, BR-13083859 Campinas, SP - Brazil
[2] Sao Paulo Res Fdn, Brazilian Inst Neurosci & Neurotechnol BRAINN, Campinas, SP - Brazil
[3] Univ Estadual Campinas, Sch Med Sci, Dept Neurol, BR-13083859 Campinas, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: AMERICAN JOURNAL OF NEURORADIOLOGY; v. 36, n. 12, p. 2214-2218, DEC 2015.
Web of Science Citations: 5
Abstract

BACKGROUND AND PURPOSE: Texture analysis is an image processing technique that can be used to extract parameters able to describe meaningful features of an image or ROI. Texture analysis based on the gray level co-occurrence matrix gives a second-order statistical description of the image or ROI. In this work, the co-occurrence matrix texture approach was used to extract information from brain MR images of patients with Friedreich ataxia and a control group, to see whether texture parameters were different between these groups. A longitudinal analysis was also performed. MATERIALS AND METHODS: Twenty patients and 21 healthy controls participated in the study. Both groups had 2 sets of Ti-weighted MR images obtained 1 year apart for every subject. ROls chosen for analysis were the medulla oblongata and pons. Texture parameters were obtained for these ROls for every subject, for the 2 sets of images. These parameters were compared longitudinally within groups and transversally between groups. RESULTS: The comparison between patients and the control group showed a significant differences for the medulla oblongata (t test, P < .05, Bonferroni-corrected) but did not show a statistically significant difference for the pons. Longitudinal comparison of images obtained 1 year apart did not show differences for either patients or for controls, in any of the analyzed structures. CONCLUSIONS: Gray level co-occurrence matrix based texture analysis showed statistically significant differences for the medulla oblongata of patients with Friedreich ataxia compared with controls. These results highlight the medulla as an important site of damage in Friedreich ataxia. (AU)

FAPESP's process: 13/07559-3 - BRAINN - The Brazilian Institute of Neuroscience and Neurotechnology
Grantee:Fernando Cendes
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 13/01766-7 - Sensory neuronopathies: investigation of new diagnostic methods, mechanisms of the disease and therapeutic strategies
Grantee:Marcondes Cavalcante Franca Junior
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 12/24363-2 - Application of the Granger causality model for the study of effective connectivity from functional magnetic resonance images acquired during verbal, visual and operating memory experiments in healthy subjects and patients with refractory epilepsy
Grantee:Márcia Silva de Oliveira
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 13/16273-6 - Characterization of texture parameters in MR brain images of healthy individuals
Grantee:Thallis Alves Santos
Support type: Scholarships in Brazil - Scientific Initiation