Usefulness of circulating E-selectin to early detection of the atherosclerotic process in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

Author(s)

de Almeida-Pititto, Bianca ^[1] ; Ribeiro-Filho, Fernando Flexa ^[2] ; Bittencourt, Marcio Sommer ^[3] ; Lotufo, Paulo A. ^[3] ; Bensenor, Isabela ^[3] ; Ferreira, Sandra R. G. ^[1]

Affiliation

^[1] Univ Sao Paulo, Sch Publ Hlth, Ave Dr Arnaldo 715, BR-01246904 Sao Paulo, SP - Brazil

^[2] Fed Univ Para, Dept Internal Med, Rua Augusto Correa, 01 Guam, BR-66075110 Belem, Para - Brazil

^[3] Univ Sao Paulo, Dept Internal Med, Ctr Pesquisa Hosp Univ, Ave Lineu Prestes 2565, 4th Floor, BR-05508000 Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: DIABETOLOGY & METABOLIC SYNDROME; v. 8, MAR 3 2016.
• Web of Science Citations: 5

Abstract

Background: This cross-sectional analysis evaluated whether determination of E-selectin concentrations could identify deterioration of cardiometabolic risk profile or subclinical atherosclerosis in individuals at low-to-moderate risk included in The Brazilian Longitudinal Study of Adult Health-ELSA-Brasil. Methods: A sample of 984 individuals from ELSA-Brasil (35-54 years) without cardiovascular disease or diabetes was stratified according to E-selectin tertiles. Traditional risk factors, inflammatory markers and categories of coronary artery calcium (CAC) scores were evaluated across the tertiles by ANOVA or Chi-squared test. In linear regression models, associations of E-selectin levels with insulin resistance index, adjusted for age, sex and adiposity were tested. Results: The mean age of the participants was 45.8 (SD 4.9) years and 55 % were women. Mean values of age, anthropometric data, biochemical variables and inflammatory status increased across E-selectin tertiles. Also, a gradual deterioration of the cardiometabolic profile was reflected by increments in frequencies (95 % CI) of BMI >= 25 kg/m(2) {[}53.7 % (48.5-58.8), 61.0 % (56.1-66.5) and 64.2 % (59.0-69.4), p = 0.019], hypertension {[}18.0 % (14.1-22.8), 19.8 % (15.4-24.6) and 24.8 % (20.4-29.9), p = 0.048], pre-diabetes {[}62.5 % (57.4-68.3), 63.1 % (58.4-69.6) and 73.8 % (68.8-78.3), p = 0.003] and hypertriglyceridemia {[}22.4 % (17.9-27.2), 27.3 % (22.5-32.8) and 33.4 % (28.3-38.5), p = 0.013]. Insulinemia and HOMA-IR were independently associated with E-selectin concentration. A greater proportion of individuals with CAC scores different from zero was found in the third tertile when compared with the first and second tertiles (16.1 versus 11 %, p = 0.04, respectively). Conclusions: Direct associations of E-selectin with traditional risk factors slightly above their normal ranges, components of the metabolic syndrome, insulin resistance and presence of CAC suggest that this biomarker may indicate an initial atherogenic process. (AU)

• FAPESP's process: 10/00074-6 - Non-traditional cardiometabolic risk factors on the spectrum of metabolic syndrome in ELSA - São Paulo
• Grantee: Bianca de Almeida Pititto
• Support Opportunities: Scholarships in Brazil - Post-Doctoral