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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

NMDA AND NON-NMDA GLUTAMATE RECEPTORS IN THE PARAVENTRICULAR NUCLEUS OF THE HYPOTHALAMUS MODULATE DIFFERENT STAGES OF HEMORRHAGE-EVOKED CARDIOVASCULAR RESPONSES IN RATS

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Author(s):
Busnardo, C. [1] ; Crestani, C. C. [2] ; Fassini, A. [1] ; Resstel, L. B. M. [1] ; Correa, F. M. A. [1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Pharmacol, Ave Bandeirantes 3900, BR-14049900 Sao Paulo - Brazil
[2] Univ Estadual Paulista UNESP, Sch Pharmaceut Sci, Araraquara, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Neuroscience; v. 320, p. 149-159, APR 21 2016.
Web of Science Citations: 0
Abstract

Here we report the involvement of N-Methyl-D-Aspartate (NMDA) and non-NMDA glutamate receptors from the paraventricular nucleus of the hypothalamus (PVN) in the mediation of cardiovascular changes observed during hemorrhage and post-bleeding periods. In addition, the present study provides further evidence of the involvement of circulating vasopressin and cardiac sympathetic activity in cardiovascular responses to hemorrhage. Systemic treatment with the V1-vasopressin receptor antagonist dTyr (CH2) 5(Me) AVP (50 mu g/kg, i.v.) increased the latency to the onset of hypotension during hemorrhage and slowed post-bleeding recovery of blood pressure. Systemic treatment with the beta(1)-adrenergic receptor antagonist atenolol (1 mg/kg, i.v.) also increased the latency to the onset of hypotension during hemorrhage. Moreover, atenolol reversed the hemorrhage-induced tachycardia into bradycardia. Bilateral microinjection of the selective NMDA glutamate receptor antagonist LY235959 (2 nmol/100 nL) into the PVN blocked the hypotensive response to hemorrhage and reduced the tachycardia during the post-hemorrhage period. Systemic treatment with dTyr(CH2)(5)(Me) AVP inhibited the effect of LY235959 on hemorrhage-induced hypotension, without affecting the post-bleeding tachycardia. PVN treatment with the selective non-NMDA receptor antagonist NBQX (2 nmol/100 nL) reduced the recovery of blood pressure to normal levels in the post-bleeding phase and reduced hemorrhage-induced tachycardia. Combined blockade of both NMDA and non-NMDA glutamate receptors in the PVN completely abolished the hypotensive response in the hemorrhage period and reduced the tachycardiac response in the post-hemorrhage period. These results indicate that local PVN glutamate neurotransmission is involved in the neural pathway mediating cardiovascular responses to hemorrhage, via an integrated control involving autonomic nervous system activity and vasopressin release into the circulation. (C) 2016 IBRO. Published by Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 13/00249-9 - Involvement of opioid neurotransmission of the medial amygadala in the mediation of autonomic and hormonal responses evoked by restraint stress in rats
Grantee:Aline Fassini
Support type: Scholarships in Brazil - Doctorate