| Grant number: |
13/00249-9
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| Support type: | Scholarships in Brazil - Doctorate |
| Effective date (Start): |
May 01, 2013
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| Effective date (End): |
June 30, 2016
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| Field of knowledge: | Biological Sciences
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Pharmacology
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Neuropsychopharmacology |
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| Principal Investigator: | Fernando Morgan de Aguiar Correa |
| Grantee: | Aline Fassini |
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| Home Institution: |
Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
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Abstract
Several structures of the central nervous system are involved in triggering stress responses through the release of neurotransmitters and neuromodulators specific. Among these structures, the amygdala is known for its role in cardiovascular, hormonal and behavioral control during aversive situations. The restraint stress is a standard model in our laboratory and has been used to evaluate autonomic changes, hormonal and behavioral disorders due to stress. The ER cause significant increase in neuronal activity of the medial nucleus of the amygdala (MeA) when compared to other amygdaloid nuclei. In addition, previous publications from our group suggest an inhibitory function of the MeA in tachycardiac response induced by ER, while the literature indicates its involvement in the hormonal release (oxytocin and corticosterone) observed during the ER. The opioid system participates of the mediating cardiovascular responses, including those associated with aversive situations. Furthermore, was showing the presence of peptides and opioid receptors in amygdala, suggesting the existence of a functional opioid neurotransmission that structure. Based on the facts mentioned above, the hypothesis of this project is that the MeA opioid neurotransmission is involved in the modulation of autonomic hormonal responses evoked by ER. Pilot experiment demonstrated the administration of naloxone in the MeA affects the cardiovascular response evoked by ER, indicating the viability of the project. (AU)
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Scientific publications
(8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
HARTMANN, ALICE;
FASSINI, ALINE;
SCOPINHO, AMERICA;
CORREA, FERNANDO M. A.;
GUIMARAES, FRANCISCO S.;
LISBOA, SABRINA F.;
RESSTEL, LEONARDO B. M.
Role of the endocannabinoid system in the dorsal hippocampus in the cardiovascular changes and delayed anxiety-like effect induced by acute restraint stress in rats.
JOURNAL OF PSYCHOPHARMACOLOGY,
v. 33,
n. 5,
p. 606-614,
MAY 2019.
Web of Science Citations: 0.