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Involvement of opioid neurotransmission of the medial amygadala in the mediation of autonomic and hormonal responses evoked by restraint stress in rats

Grant number: 13/00249-9
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): May 01, 2013
Effective date (End): June 30, 2016
Field of knowledge:Biological Sciences - Pharmacology - Neuropsychopharmacology
Principal researcher:Fernando Morgan de Aguiar Correa
Grantee:Aline Fassini
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Several structures of the central nervous system are involved in triggering stress responses through the release of neurotransmitters and neuromodulators specific. Among these structures, the amygdala is known for its role in cardiovascular, hormonal and behavioral control during aversive situations. The restraint stress is a standard model in our laboratory and has been used to evaluate autonomic changes, hormonal and behavioral disorders due to stress. The ER cause significant increase in neuronal activity of the medial nucleus of the amygdala (MeA) when compared to other amygdaloid nuclei. In addition, previous publications from our group suggest an inhibitory function of the MeA in tachycardiac response induced by ER, while the literature indicates its involvement in the hormonal release (oxytocin and corticosterone) observed during the ER. The opioid system participates of the mediating cardiovascular responses, including those associated with aversive situations. Furthermore, was showing the presence of peptides and opioid receptors in amygdala, suggesting the existence of a functional opioid neurotransmission that structure. Based on the facts mentioned above, the hypothesis of this project is that the MeA opioid neurotransmission is involved in the modulation of autonomic hormonal responses evoked by ER. Pilot experiment demonstrated the administration of naloxone in the MeA affects the cardiovascular response evoked by ER, indicating the viability of the project. (AU)

Scientific publications (8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
HARTMANN, ALICE; FASSINI, ALINE; SCOPINHO, AMERICA; CORREA, FERNANDO M. A.; GUIMARAES, FRANCISCO S.; LISBOA, SABRINA F.; RESSTEL, LEONARDO B. M. Role of the endocannabinoid system in the dorsal hippocampus in the cardiovascular changes and delayed anxiety-like effect induced by acute restraint stress in rats. JOURNAL OF PSYCHOPHARMACOLOGY, v. 33, n. 5, p. 606-614, MAY 2019. Web of Science Citations: 0.
BRASIL, TAIZ F. S.; FASSINI, ALINE; CORREA, FERNANDO M. AT1 and AT2 Receptors in the Prelimbic Cortex Modulate the Cardiovascular Response Evoked by Acute Exposure to Restraint Stress in Rats. Cellular and Molecular Neurobiology, v. 38, n. 1, SI, p. 305-316, JAN 2018. Web of Science Citations: 0.
FASSINI, ALINE; SCOPINHO, AMERICA A.; ALVES, FERNANDO H. F.; FORTALEZA, EDUARDO A. T.; CORREA, FERNANDO M. A. THE MEDIAL PREOPTIC AREA MODULATES AUTONOMIC FUNCTION UNDER RESTING AND STRESS CONDITIONS. Neuroscience, v. 364, p. 164-174, NOV 19 2017. Web of Science Citations: 1.
FASSINI, ALINE; SCOPINHO, AMERICA A.; RESSTEL, LEONARDO B. M.; CORREA, FERNANDO M. A. NOP receptors in the prelimbic cortex have an inhibitory influence on cardiovascular responses induced by restraint stress. Neuropeptides, v. 57, p. 35-44, JUN 2016. Web of Science Citations: 2.
BUSNARDO, C.; CRESTANI, C. C.; FASSINI, A.; RESSTEL, L. B. M.; CORREA, F. M. A. NMDA AND NON-NMDA GLUTAMATE RECEPTORS IN THE PARAVENTRICULAR NUCLEUS OF THE HYPOTHALAMUS MODULATE DIFFERENT STAGES OF HEMORRHAGE-EVOKED CARDIOVASCULAR RESPONSES IN RATS. Neuroscience, v. 320, p. 149-159, APR 21 2016. Web of Science Citations: 0.
FASSINI, ALINE; RESSTEL, LEONARDO B. M.; CORREA, FERNANDO M. A. Prelimbic cortex GABA(A) receptors are involved in the mediation of restraint stress-evoked cardiovascular responses. STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS, v. 19, n. 6, p. 576-584, 2016. Web of Science Citations: 2.
FASSINI, ALINE; SCOPINHO, AMERICA A.; RESSTEL, LEONARDO B. M.; CORREA, FERNANDO M. A. kappa-Opioid receptors in the infralimbic cortex modulate the cardiovascular responses to acute stress. Experimental Physiology, v. 100, n. 4, p. 377-387, APR 2015. Web of Science Citations: 4.
FASSINI, ALINE; SCOPINHO, AMERICA A.; RESSTEL, LEONARDO B. M.; CORREA, FERNANDO M. A. Opioid receptors in the prelimbic cortex modulate restraint stress-induced cardiovascular responses in the rat. Neuropharmacology, v. 85, p. 367-374, OCT 2014. Web of Science Citations: 6.

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