| Full text | |
| Author(s): |
Bohlen, Tabata M.
[1]
;
Silveira, Marina A.
[1]
;
Zampieri, Thais T.
[2]
;
Frazao, Renata
[1]
;
Donato, Jr., Jose
[2]
Total Authors: 5
|
| Affiliation: | [1] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo, SP - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | Molecular and Cellular Endocrinology; v. 423, n. C, p. 11-21, MAR 5 2016. |
| Web of Science Citations: | 12 |
| Abstract | |
Leptin is a permissive factor for the onset of puberty. However, changes in adiposity frequently influence leptin sensitivity. Thus, the objective of the present study was to investigate how changes in body weight, fatness, leptin levels and leptin sensitivity interact to control the timing of puberty in female mice. Prepubertal obesity, induced by raising C57BL/6 mice in small litters, led to an early puberty onset. Inactivation of Socs3 gene in the brain or exclusively in leptin receptor-expressing cells reduced the body weight and leptin levels at pubertal onset, and increased leptin sensitivity. Notably, these female mice exhibited significant delays in vaginal opening, first estrus and onset of estrus cyclicity. In conclusion, our findings suggest that increased leptin sensitivity did not play an important role in favoring pubertal onset in female mice. Rather, changes in pubertal body weight, fatness and/or leptin levels were more important in influencing the timing of puberty. (C) 2016 Elsevier Ireland Ltd. All rights reserved. (AU) | |
| FAPESP's process: | 10/18086-0 - Molecular basis of leptin resistance |
| Grantee: | Jose Donato Junior |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 12/12202-4 - Kiss1 neurons biophysical properties modulation by circadian factors |
| Grantee: | Renata Frazão |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 12/15517-6 - Involvment of molecular factors in metabolic changes during pregnancy: role of SOCS3 |
| Grantee: | Thais Tessari Zampieri |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 13/07908-8 - Precocious puberty in childhood obesity: possible mechanisms and influence of leptin |
| Grantee: | Renata Frazão |
| Support Opportunities: | Regular Research Grants |