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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Influence of osteoporosis on the osteocyte density of human mandibular bone samples: a controlled histological human study

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Author(s):
Oliveira, Pablo S. [1] ; Rodrigues, Jose A. [1] ; Shibli, Jamil A. [1] ; Piattelli, Adriano [2] ; Iezzi, Giovanna [2] ; Perrotti, Vittoria [2]
Total Authors: 6
Affiliation:
[1] Univ Guarulhos, Dent Res Div, Dept Periodontol & Oral Implantol, Guarulhos - Brazil
[2] Univ G dAnnunzio, Dept Med Oral & Biotechnol Sci, Chieti - Italy
Total Affiliations: 2
Document type: Journal article
Source: Clinical Oral Implants Research; v. 27, n. 3, p. 325-328, MAR 2016.
Web of Science Citations: 6
Abstract

ObjectivesOsteocytes have emerged as key regulators of skeletal and mineral homeostasis. The number of these cells could be influenced by the presence of osteoporosis and osteopenia. Hence, the aim this study was to evaluate the osteocyte density in patients with osteopenia, and in patients with osteoporosis treated with bisphosphonates. Materials and methodsThirty-nine patients were selected for this study and divided into three groups: (A) nine healthy patients (control), (B) 15 patients with osteopenia, and (C) 15 patients with osteoporosis. During the surgical insertion of dental implants in the lower jaw, bone samples were retrieved and processed for histological analysis of osteocyte density, measured as number of osteocytes/bone tissue area (m(2)). ResultsPatients with osteopenia showed statistically higher values of osteocyte density than patients with osteoporosis (P<0.05) No significant differences were detected between osteopenia and osteoporosis subjects vs. healthy patients (P>0.05). ConclusionsBone metabolism diseases (osteoporosis and osteopenia) do not seem to influence the osteocyte density; this could be due to the administration of bisphosphonates in patients with osteoporosis. This information could play a fundamental role in the diagnosis and treatment of patients in a postmenopausal stage. (AU)

FAPESP's process: 08/06972-6 - Influence of Type I Osteoporosis on osseointegration of immediate actived implants
Grantee:Jamil Awad Shibli
Support Opportunities: Regular Research Grants