Structural covariance of neostriatal and limbic regions in patients with obsessive-compulsive disorder

Author(s):Show less -

Subira, Marta ^{[1, 2, 3]} ; Cano, Marta ^{[1, 2]} ; de Wit, Stella J. ^{[4, 5]} ; Alonso, Pino ^{[1, 2, 3]} ; Cardoner, Narcis ^{[1, 6, 7]} ; Hoexter, Marcelo Q. ^[8] ; Kwon, Jun Soo ^{[9, 10]} ; Nakamae, Takashi ^[11] ; Lochner, Christine ^[12] ; Sato, Joao R. ^[13] ; Jung, Wi Hoon ^[10] ; Narumoto, Jin ^[11] ; Stein, Dan J. ^[14] ; Pujol, Jesus ^{[15, 3, 16]} ; Mataix-Cols, David ^[17] ; Veltman, Dick J. ^{[4, 5]} ; Menchon, Jose M. ^{[1, 2, 3]} ; van den Heuvel, Odile A. ^{[4, 5]} ; Soriano-Mas, Carles ^{[1, 3, 18]} ; Consortium, OCD Brain Imaging

Affiliation:Show less -

^[1] Bellvitge Univ Hosp, Bellvitge Biomed Res Inst IDIBELL, Dept Psychiat, Barcelona 08907 - Spain

^[2] Univ Barcelona, Sch Med, Dept Clin Sci, Barcelona - Spain

^[3] Carlos III Hlth Inst, Ctr Invest Biomed Red Salud Mental CIBERSAM, Barcelona - Spain

^[4] Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, Amsterdam - Netherlands

^[5] Vrije Univ Amsterdam, Med Ctr, Dept Anat & Neurosci, Amsterdam - Netherlands

^[6] Corporacio Sanitaria Parc Tauli, Dept Mental Hlth, Sabadell - Spain

^[7] Univ Autonoma Barcelona, Dept Psychiat & Forens Med, E-08193 Barcelona - Spain

^[8] Univ Sao Paulo, Sch Med, Dept & Inst Psychiat, Sao Paulo - Brazil

^[9] Seoul Natl Univ, Coll Med, Dept Psychiat, Seoul - South Korea

^[10] SNU MRC, Inst Human Behav Med, Seoul - South Korea

^[11] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Psychiat, Kyoto - Japan

^[12] Univ Stellenbosch, Dept Psychiat, MRC Unit Anxiety & Stress Disorders, ZA-7600 Stellenbosch - South Africa

^[13] Univ Fed ABC, Ctr Math Computat & Cognit, Santo Andre - Brazil

^[14] Univ Cape Town, Dept Psychiat & Mental Hlth, ZA-7925 Cape Town - South Africa

^[15] Hosp del Mar, CRC Mar, MRI Res Unit, Barcelona - Spain

^[16] CIBERSAM G21, Ctr Invest Biomed Red Salud Mental, Barcelona - Spain

^[17] Karolinska Inst, Dept Clin Neurosci, Stockholm - Sweden

^[18] Autonomous Univ Barcelona, Dept Psychobiol & Methodol Hlth Sci, Barcelona - Spain

• Document type: Journal article
• Source: JOURNAL OF PSYCHIATRY & NEUROSCIENCE; v. 41, n. 2, p. 115-123, MAR 2016.
• Web of Science Citations: 10

Abstract

Background Frontostriatal and frontoamygdalar connectivity alterations in patients with obsessive-compulsive disorder (OCD) have been typically described in functional neuroimaging studies. However, structural covariance, or volumetric correlations across distant brain regions, also provides network-level information. Altered structural covariance has been described in patients with different psychiatric disorders, including OCD, but to our knowledge, alterations within frontostriatal and frontoamygdalar circuits have not been explored. Methods We performed a mega-analysis pooling structural MRI scans from the Obsessive-compulsive Brain Imaging Consortium and assessed whole-brain voxel-wise structural covariance of 4 striatal regions (dorsal and ventral caudate nucleus, and dorsal-caudal and ventral-rostral putamen) and 2 amygdalar nuclei (basolateral and centromedial-superficial). Images were preprocessed with the standard pipeline of voxel-based morphometry studies using Statistical Parametric Mapping software. Results Our analyses involved 329 patients with OCD and 316 healthy controls. Patients showed increased structural covariance between the left ventral-rostral putamen and the left inferior frontal gyrus/frontal operculum region. This finding had a significant interaction with age; the association held only in the subgroup of older participants. Patients with OCD also showed increased structural covariance between the right centromedial-superficial amygdala and the ventromedial prefrontal cortex. Limitations This was a cross-sectional study. Because this is a multisite data set analysis, participant recruitment and image acquisition were performed in different centres. Most patients were taking medication, and treatment protocols differed across centres. Conclusion Our results provide evidence for structural network-level alterations in patients with OCD involving 2 frontosubcortical circuits of relevance for the disorder and indicate that structural covariance contributes to fully characterizing brain alterations in patients with psychiatric disorders. (AU)

• FAPESP's process: 13/10498-6 - Machine learning in neuroimaging: development of methods and clinical applications in psychiatric disorders
• Grantee: João Ricardo Sato
• Support Opportunities: Regular Research Grants